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dc.contributor.authorMcCallum, Katie
dc.contributor.authorWatson, Penelope
dc.date.accessioned2018-07-30T08:57:38Z
dc.date.available2018-07-30T08:57:38Z
dc.date.issued2018-03-01
dc.identifier.issn2052-6121
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/278530
dc.description.abstractA one-year-old neutered male Border collie presented with failure to gain weight, lethargy, intermittent leucopenia, borderline anaemia and intermittent gastrointestinal symptoms. He was diagnosed with pancreatitis based on blood results and abdominal ultrasonography and hereditary selective cobalamin malabsorption based on hypocobalaminaemia, methylmalonic aciduria and genetic testing for cubilin mutation. The dog responded to oral cobalamin supplementation with resolution of clinical signs and normalisation of serum cobalamin. There was no recurrence of signs after 27 months of follow-up. An association between organic acidaemias and pancreatitis has been reported in humans but to the authors' knowledge, this is the first report of hereditary selective cobalamin malabsorption and concurrent pancreatitis in a dog. Furthermore, this is the first report of inherited canine cobalamin deficiency responding to oral cobalamin supplementation.
dc.description.sponsorshipThis research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.
dc.languageeng
dc.publisherBMJ
dc.titleHereditary selective cobalamin malabsorption and concurrent pancreatitis in a young Border collie
dc.typeArticle
prism.issueIdentifier1
prism.numbere000568
prism.publicationDate2018
prism.publicationNameVeterinary Record Case Reports
prism.volume6
dc.identifier.doi10.17863/CAM.24720
dcterms.dateAccepted2018-02-14
rioxxterms.versionofrecord10.1136/vetreccr-2017-000568
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-03-01
dc.contributor.orcidMcCallum, Katie [0000-0001-6153-0687]
dc.contributor.orcidWatson, Penelope [0000-0002-7241-9412]
dc.identifier.eissn2052-6121
dc.publisher.urlhttps://vetrecordcasereports.bmj.com/content/6/1/e000568
rioxxterms.typeJournal Article/Review
cam.issuedOnline2078-03-03
dc.identifier.urlhttps://vetrecordcasereports.bmj.com/content/6/1/e000568


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