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dc.contributor.authorDean, Pen
dc.contributor.authorSendra, KMen
dc.contributor.authorWilliams, TAen
dc.contributor.authorWatson, AKen
dc.contributor.authorMajor, Pen
dc.contributor.authorNakjang, Sen
dc.contributor.authorKozhevnikova, Een
dc.contributor.authorGoldberg, AVen
dc.contributor.authorKunji, Edmunden
dc.contributor.authorHirt, RPen
dc.contributor.authorEmbley, TMen
dc.date.accessioned2018-08-07T16:27:42Z
dc.date.available2018-08-07T16:27:42Z
dc.date.issued2018-04-27en
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/278691
dc.description.abstractThe acquisition of genes by horizontal transfer can impart entirely new biological functions and provide an important route to major evolutionary innovation. Here we have used ancient gene reconstruction and functional assays to investigate the impact of a single horizontally transferred nucleotide transporter into the common ancestor of the Microsporidia, a major radiation of intracellular parasites of animals and humans. We show that this transporter provided early microsporidians with the ability to steal host ATP and to become energy parasites. Gene duplication enabled the diversification of nucleotide transporter function to transport new substrates, including GTP and NAD+, and to evolve the proton-energized net import of nucleotides for nucleic acid biosynthesis, growth and replication. These innovations have allowed the loss of pathways for mitochondrial and cytosolic energy generation and nucleotide biosynthesis that are otherwise essential for free-living eukaryotes, resulting in the highly unusual and reduced cells and genomes of contemporary Microsporidia.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCell Lineen
dc.subjectAnimalsen
dc.subjectRabbitsen
dc.subjectNucleotidesen
dc.subjectNucleotide Transport Proteinsen
dc.subjectEvolution, Molecularen
dc.subjectPhylogenyen
dc.subjectGene Duplicationen
dc.subjectGene Transfer, Horizontalen
dc.subjectGenome, Fungalen
dc.subjectMicrosporidiaen
dc.subjectMetabolic Networks and Pathwaysen
dc.subjectHost-Pathogen Interactionsen
dc.titleTransporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2018en
prism.publicationNameNature communicationsen
prism.startingPage1709
prism.volume9en
dc.identifier.doi10.17863/CAM.26048
dcterms.dateAccepted2018-03-22en
rioxxterms.versionofrecord10.1038/s41467-018-03923-4en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-04-27en
dc.contributor.orcidDean, P [0000-0002-2822-4677]
dc.contributor.orcidWilliams, TA [0000-0003-1072-0223]
dc.contributor.orcidMajor, P [0000-0002-6443-5631]
dc.contributor.orcidKunji, Edmund [0000-0002-0610-4500]
dc.contributor.orcidHirt, RP [0000-0002-3760-9958]
dc.contributor.orcidEmbley, TM [0000-0002-1484-340X]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_U105663139)
pubs.funder-project-idBBSRC (BB/R50564X/1)
pubs.funder-project-idMRC (MC_UU_00015/1)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International