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dc.contributor.authorDearden, Lauraen
dc.contributor.authorBouret, Sebastien Gen
dc.contributor.authorOzanne, Susanen
dc.date.accessioned2018-08-16T16:50:42Z
dc.date.available2018-08-16T16:50:42Z
dc.date.issued2018-09en
dc.identifier.issn2212-8778
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/278902
dc.description.abstractThe early life environment experienced by an individual in utero and during the neonatal period is a major factor in shaping later life disease risk-including susceptibility to develop obesity, diabetes, and cardiovascular disease. The incidence of metabolic disease is different between males and females. How the early life environment may underlie these sex differences is an area of active investigation. Scope of Review The purpose of this review is to summarize our current understanding of how the early life environment influences metabolic disease risk in a sex specific manner. We also discuss the possible mechanisms responsible for mediating these sexually dimorphic effects and highlight the results of recent intervention studies in animal models. Major conclusions Exposure to states of both under- and over-nutrition during early life predisposes both sexes to develop metabolic disease. Females seem particularly susceptible to develop increased adiposity and disrupted glucose homeostasis as a result of exposure to in utero undernutrition or high sugar environments, respectively. The male placenta is particularly vulnerable to damage by adverse nutritional states and this may underlie some of the metabolic phenotypes observed in adulthood. More studies investigating both sexes are needed to understand how changes to the early life environment impact differently on the long-term health of male and female individuals.
dc.description.sponsorshipWellcome Trust, MRC, NIH, Foundation for Prader-Willi Research, The Saban Research Institute
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHumansen
dc.subjectMetabolic Diseasesen
dc.subjectSex Factorsen
dc.subjectEnergy Metabolismen
dc.subjectEmbryonic Developmenten
dc.subjectSex Characteristicsen
dc.subjectFemaleen
dc.subjectMaleen
dc.titleSex and gender differences in developmental programming of metabolism.en
dc.typeArticle
prism.endingPage19
prism.publicationDate2018en
prism.publicationNameMolecular metabolismen
prism.startingPage8
prism.volume15en
dc.identifier.doi10.17863/CAM.26283
dcterms.dateAccepted2018-04-23en
rioxxterms.versionofrecord10.1016/j.molmet.2018.04.007en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-09en
dc.contributor.orcidDearden, Laura [0000-0002-0804-074X]
dc.contributor.orcidOzanne, Susan [0000-0001-8753-5144]
dc.identifier.eissn2212-8778
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (106026/Z/14/Z)
pubs.funder-project-idMRC (MC_UU_12012/4)
pubs.funder-project-idMRC (MC_UU_12012/5)
pubs.funder-project-idBritish Heart Foundation (RG/17/12/33167)
pubs.funder-project-idWellcome Trust (089939/Z/09/Z)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International