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dc.contributor.authorBarnes, Annaen
dc.contributor.authorAlonzi, Robertoen
dc.contributor.authorBlackledge, Matthewen
dc.contributor.authorCharles-Edwards, Geoffen
dc.contributor.authorCollins, David Jen
dc.contributor.authorCook, Garyen
dc.contributor.authorCoutts, Glynnen
dc.contributor.authorGoh, Vickyen
dc.contributor.authorGraves, Martinen
dc.contributor.authorKelly, Charlesen
dc.contributor.authorKoh, Dow-Muen
dc.contributor.authorMcCallum, Hazelen
dc.contributor.authorMiquel, Marc Een
dc.contributor.authorO'Connor, Jamesen
dc.contributor.authorPadhani, Anwaren
dc.contributor.authorPearson, Rachelen
dc.contributor.authorPriest, Andrewen
dc.contributor.authorRockall, Andreaen
dc.contributor.authorStirling, Jamesen
dc.contributor.authorTaylor, Stuarten
dc.contributor.authorTunariu, Ninaen
dc.contributor.authorvan der Meulen, Janen
dc.contributor.authorWalls, Darrenen
dc.contributor.authorWinfield, Jessicaen
dc.contributor.authorPunwani, Shoniten
dc.date.accessioned2018-08-29T10:11:19Z
dc.date.available2018-08-29T10:11:19Z
dc.date.issued2018-01en
dc.identifier.issn0007-1285
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279029
dc.description.abstractOBJECTIVE: Application of whole body diffusion-weighted MRI (WB-DWI) for oncology are rapidly increasing within both research and routine clinical domains. However, WB-DWI as a quantitative imaging biomarker (QIB) has significantly slower adoption. To date, challenges relating to accuracy and reproducibility, essential criteria for a good QIB, have limited widespread clinical translation. In recognition, a UK workgroup was established in 2016 to provide technical consensus guidelines (to maximise accuracy and reproducibility of WB-MRI QIBs) and accelerate the clinical translation of quantitative WB-DWI applications for oncology. METHODS: A panel of experts convened from cancer centres around the UK with subspecialty expertise in quantitative imaging and/or the use of WB-MRI with DWI. A formal consensus method was used to obtain consensus agreement regarding best practice. Questions were asked about the appropriateness or otherwise on scanner hardware and software, sequence optimisation, acquisition protocols, reporting, and ongoing quality control programs to monitor precision and accuracy and agreement on quality control. RESULTS: The consensus panel was able to reach consensus on 73% (255/351) items and based on consensus areas made recommendations to maximise accuracy and reproducibly of quantitative WB-DWI studies performed at 1.5T. The panel were unable to reach consensus on the majority of items related to quantitative WB-DWI performed at 3T. CONCLUSION: This UK Quantitative WB-DWI Technical Workgroup consensus provides guidance on maximising accuracy and reproducibly of quantitative WB-DWI for oncology. The consensus guidance can be used by researchers and clinicians to harmonise WB-DWI protocols which will accelerate clinical translation of WB-DWI-derived QIBs.
dc.languageengen
dc.publisherBritish Institute of Radiology
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDiffusion Magnetic Resonance Imagingen
dc.subjectHumansen
dc.subjectMedical Oncologyen
dc.subjectNeoplasmsen
dc.subjectQuality Controlen
dc.subjectUnited Kingdomen
dc.subjectWhole Body Imagingen
dc.titleUK quantitative WB-DWI technical workgroup: consensus meeting recommendations on optimisation, quality control, processing and analysis of quantitative whole-body diffusion-weighted imaging for cancer.en
dc.typeArticle
prism.endingPage20170577
prism.issueIdentifier1081en
prism.publicationDate2018en
prism.publicationNameBritish Journal of Radiologyen
prism.startingPage20170577
prism.volume91en
dc.identifier.doi10.17863/CAM.26405
dcterms.dateAccepted2017-10-11en
rioxxterms.versionofrecord10.1259/bjr.20170577en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-01en
dc.contributor.orcidGraves, Martin [0000-0003-4327-3052]
dc.identifier.eissn1748-880X
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2017-12-07en
dc.identifier.urlhttps://www.birpublications.org/doi/10.1259/bjr.20170577en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International