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dc.contributor.authorBarbera, Mariagneseen
dc.contributor.authorMangialasche, Francescaen
dc.contributor.authorJongstra, Susanen
dc.contributor.authorGuillemont, Julietteen
dc.contributor.authorNgandu, Tiiaen
dc.contributor.authorBeishuizen, Cathrienen
dc.contributor.authorColey, Nicolaen
dc.contributor.authorBrayne, Carolen
dc.contributor.authorAndrieu, Sandrineen
dc.contributor.authorRichard, Edoen
dc.contributor.authorSoininen, Hilkkaen
dc.contributor.authorKivipelto, Miiaen
dc.contributor.authorHATICE study group,en
dc.date.accessioned2018-08-30T09:30:31Z
dc.date.available2018-08-30T09:30:31Z
dc.date.issued2018-02-20en
dc.identifier.issn1875-8908
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279037
dc.description.abstractBACKGROUND: Many dementia and cardiovascular disease (CVD) cases in older adults are attributable to modifiable vascular and lifestyle-related risk factors, providing opportunities for prevention. In the Healthy Aging Through Internet Counselling in the Elderly (HATICE) randomized controlled trial, an internet-based multidomain intervention is being tested to improve the cardiovascular risk (CVR) profile of older adults. OBJECTIVE: To design a multidomain intervention to improve CVR, based on the guidelines for CVR management, and administered through a coach-supported, interactive, platform to over 2500 community-dwellers aged 65+ in three European countries. METHODS: A comparative analysis of national and European guidelines for primary and secondary CVD prevention was performed. Results were used to define the content of the intervention. RESULTS: The intervention design focused on promoting awareness and self-management of hypertension, dyslipidemia, diabetes mellitus, and overweight, and supporting smoking cessation, physical activity, and healthy diet. Overall, available guidelines lacked specific recommendations for CVR management in older adults. The comparative analysis of the guidelines showed general consistency for lifestyle-related recommendations. Key differences, identified mostly in methods used to assess the overall CVR, did not hamper the intervention design. Minor country-specific adaptations were implemented to maximize the intervention feasibility in each country. CONCLUSION: Despite differences in CVR management within the countries considered, it was possible to design and implement the HATICE multidomain intervention. The study can help define preventative strategies for dementia and CVD that are applicable internationally.
dc.description.sponsorshipThe research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 305374. The study has also been funded by the “Multimodal preventive trials for Alzheimer’s Disease: towards multinational strategies-programme: MIND-AD”, Academy of Finland (291803) and VTR, Kuopio University Hospital (5772815), Swedish Research Council (529-2014-7503), The Stockholms Sjukhem foundation, the Netherlands Organization for Health Research and Development, (733051041), and the French National Research Agency (ANR-14-JPPS-0001-02).
dc.languageengen
dc.publisherIOS Press
dc.subjectCardiovascular disease preventionen
dc.subjectcardiovascular risk factorsen
dc.subjectdementia preventionen
dc.subjecte-Healthen
dc.subjectmultidomain interventionen
dc.titleDesigning an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults: The HATICE Trial.en
dc.typeArticle
prism.endingPage663
prism.issueIdentifier2en
prism.publicationDate2018en
prism.publicationNameJournal of Alzheimer's Diseaseen
prism.startingPage649
prism.volume62en
dc.identifier.doi10.17863/CAM.24592
dcterms.dateAccepted2017-12-08en
rioxxterms.versionofrecord10.3233/JAD-170858en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-02-20en
dc.contributor.orcidBrayne, Carol [0000-0001-5307-663X]
dc.identifier.eissn1875-8908
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2018-02-20en
dc.identifier.urlhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad170858en


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