Preparation and evaluation of smart nanocarrier systems for drug delivery using magnetic nanoparticle and avidin-iminobiotin system
Publication Date
2018Journal Title
Journal of Nanomaterials
ISSN
1687-4110
Publisher
Hindawi Limited
Type
Journal Article
Metadata
Show full item recordCitation
Sun, S., Li, B., Yang, T., Ma, M., Lin, Q., Zhao, J., & Luo, F. (2018). Preparation and evaluation of smart nanocarrier systems for drug delivery using magnetic nanoparticle and avidin-iminobiotin system. [Journal Article]. https://doi.org/10.1155/2018/1627879
Abstract
<jats:p>Therapeutic efficacy and the regulation of drug release can be improved by using selective targeting drug delivery systems. In this paper, we have demonstrated avidin-immobilized magnetic nanoparticles (AMNPs) as a novel targeted drug delivery system to deliver iminobiotinylated daunomycin (IDAU). TEM, XRD, VSM, and FTIR were employed for the physicochemical characterization of the drug-loaded MNPs. The binding of IDAU had little effect on sizes of AMNPs (~35 nm), but the stability and dispersibility of the nanoparticles were improved. The study also found that the loading capacity and efficiency of nanoparticles were mainly dependent on affinity interaction between IDAU and AMNPs. The optimal loading capacity and efficiency of MNPs for IDAU were 0.408 ± 0.012 mg/g and 94.18 ± 2.64% according to the reversed-phase high-performance liquid chromatography (RP-HPLC) data, respectively. Under the conditions of pH 6.8 and 1 mmol/L of biotin, the drug-loaded MNPs released rapidly at beginning and then maintained at a certain controllable release level. The effect of IDAU on DLKP proliferation was tested, and the results showed that IC50 was (1.60 ± 0.05) × 10<jats:sup>−3</jats:sup> mg/mL. Our findings indicated that AMNPs hold tremendous potential as an effective drug delivery system.</jats:p>
Identifiers
External DOI: https://doi.org/10.1155/2018/1627879
This record's DOI: https://doi.org/10.17863/CAM.26437
Rights
Rights Holder: Copyright © 2018 Shuguo Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk