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dc.contributor.authorMiller, Sophie Ren
dc.contributor.authorBenito, Cristinaen
dc.contributor.authorMirsky, Rhonaen
dc.contributor.authorJessen, Kristján Ren
dc.contributor.authorBaker, Clareen
dc.date.accessioned2018-09-05T12:39:47Z
dc.date.available2018-09-05T12:39:47Z
dc.date.issued2018-06en
dc.identifier.issn1526-954X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279332
dc.description.abstractThe neural crest-derived ensheathing glial cells of the olfactory nerve (OECs) are unique in spanning both the peripheral and central nervous systems: they ensheathe bundles of axons projecting from olfactory receptor neurons in the nasal epithelium to their targets in the olfactory bulb. OECs are clinically relevant as a promising autologous cell transplantation therapy for promoting central nervous system repair. They are also important for fertility, being required for the migration of embryonic gonadotropin-releasing hormone (GnRH) neurons from the olfactory placode along terminal nerve axons to the medial forebrain, which they enter caudal to the olfactory bulbs. Like Schwann cell precursors, OEC precursors associated with the developing olfactory nerve express the glial marker myelin protein zero and the key peripheral glial transcription factor Sox10. The transition from Schwann cell precursors to immature Schwann cells is accelerated by canonical Notch signalling via the Rbpj transcription factor. Here, we aimed to test the role of Notch/Rbpj signalling in developing OECs by blocking the pathway in both chicken and mouse. Our results suggest that Notch/Rbpj signalling prevents the cranial neural crest cells that colonise the olfactory nerve from differentiating as neurons, and at later stages contributes to the guidance of GnRH neurons.
dc.description.sponsorshipAnatomical Society
dc.format.mediumPrinten
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectOlfactory Bulben
dc.subjectNeurogliaen
dc.subjectNeuronsen
dc.subjectChick Embryoen
dc.subjectNeural Cresten
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectSignal Transductionen
dc.subjectCell Differentiationen
dc.subjectCell Movementen
dc.subjectImmunoglobulin J Recombination Signal Sequence-Binding Proteinen
dc.subjectReceptors, Notchen
dc.subjectGonadotropin-Releasing Hormoneen
dc.subjectNeurogenesisen
dc.titleNeural crest Notch/Rbpj signaling regulates olfactory gliogenesis and neuronal migration.en
dc.typeArticle
prism.issueIdentifier6-7en
prism.publicationDate2018en
prism.publicationNameGenesis (New York, N.Y. : 2000)en
prism.startingPagee23215
prism.volume56en
dc.identifier.doi10.17863/CAM.26710
dcterms.dateAccepted2018-05-04en
rioxxterms.versionofrecord10.1002/dvg.23215en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-06en
dc.contributor.orcidBaker, Clare [0000-0002-4434-3107]
dc.identifier.eissn1526-968X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idAnatomical Society (AS) (30058)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)