Neurodegeneration: from molecules to medicines
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Authors
Mallucci, G
Publication Date
2017Journal Title
JOURNAL OF NEUROCHEMISTRY
Conference Name
ISN-ESN 2017 Meeting
ISSN
0022-3042
Publisher
Wiley
Volume
142
Pages
9-9
Type
Conference Object
Metadata
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Mallucci, G. (2017). Neurodegeneration: from molecules to medicines. JOURNAL OF NEUROCHEMISTRY, 142 9-9. https://doi.org/10.1111/jnc.14086
Abstract
This talk will cover our recent progress in understanding
mechanisms of neurodegeneration and how this is informing new
therapeutic approaches. The central concept is the identification of
common pathways across the spectrum of these disorders (which
include Alzheimer ’s and related diseases) that are relevant for both
mechanistic insights and therapy. These include both ‘toxic’
processes that can be targeted to prevent neuronal death, and
regenerative processes that can be harnessed for repair. I will discuss
our data in mouse models targeting both of these aspects to prevent
neurodegeneration and their relevance for human disease. I will
focus on modulating the Unfolded Protein Response pharmacolog-
ically and the recent discovery of repurposed drugs ready for clinical
trials. I will also discuss the strategy of harnessing pathways that
drive synapse regeneration, as occurs in hibernation, for the therapy
of neurodegeneration.
Sponsorship
Alzheimer's Drug Discovery Foundation (20141103)
European Research Council (647479)
Identifiers
External DOI: https://doi.org/10.1111/jnc.14086
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279367
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Licence:
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