Repository logo
 

Neuromodulator interactions and spinal cord injury in lamprey.

Accepted version
Peer-reviewed

No Thumbnail Available

Type

Article

Change log

Authors

McClelland, Thomas J 

Abstract

Neuromodulation is mediated by neurotransmitters that typically act on G-protein-coupled receptors. It can confer behavioural flexibility by modifying the functional properties of anatomically hard-wired neural circuits. Single neuromodulators generally have divergent cellular and synaptic effects (Harris-Warrick and Johnson, 2010), and different modulators, of which there are many in even simpler systems, can interact by converging onto the same effectors. These interactions can generate synergistic, antagonistic, or novel effects (see Harris-Warrick and Johnson, 2010). Further modulator complexity is offered by the potential for concentration, time, and state-dependent influences (see Parker, 2015 and references therein). All of these effects can make neuromodulation highly flexible, making it difficult to predict or explain the functional effects resulting from the targeting of even a single modulatory system. As many clinically used drugs target G-protein-coupled receptors, being able to explain and predict these effects is important.

Description

Keywords

32 Biomedical and Clinical Sciences, 3209 Neurosciences

Journal Title

Neural Regen Res

Conference Name

Journal ISSN

1673-5374
1876-7958

Volume Title

13

Publisher

Medknow
Sponsorship
No funding