Optoacoustic Imaging Detects Hormone-Related Physiological Changes of Breast Parenchyma.
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Authors
Abeyakoon, Oshaani
Morscher, Stefan
Dalhaus, Nina
Ford, Steven J
Mendichovszky, Iosif
Wallis, Matthew
Moyle, Penelope
Patterson, Andrew
Gonzalez, Isabel Quiros
Publication Date
2019-12Journal Title
Ultraschall in der Medizin (Stuttgart, Germany : 1980)
ISSN
0172-4614
Publisher
Thieme
Volume
40
Issue
6
Pages
757-763
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Abeyakoon, O., Morscher, S., Dalhaus, N., Ford, S. J., Mendichovszky, I., Manavaki, R., Wallis, M., et al. (2019). Optoacoustic Imaging Detects Hormone-Related Physiological Changes of Breast Parenchyma.. Ultraschall in der Medizin (Stuttgart, Germany : 1980), 40 (6), 757-763. https://doi.org/10.1055/a-0628-6248
Abstract
Optoacoustic (OA) imaging is an emerging low-cost hybrid imaging modality currently in clinical feasibility studies for breast cancer diagnosis and staging (1–7). The technique applies pulsed light to the tissue of interest, where molecules absorb the light photons and generate acoustic pressure waves. The resulting acoustic responses are detected using ultrasound transducers and converted into images. Image contrast
within a pixel is dependent on the relative concentration and absorption characteristics (i.e. spectrum) of the chromophores within the illuminated tissue. Thus, tissue responses from illumination using multiple wavelengths, chosen to reflect the differential absorption of oxy, deoxy and total haemoglobin (Hb), can be measured. In turn, these signals can be regarded as surrogate measures of tissue hypoxia
and neoangiogenesis, hallmarks of cancer associated with adverse outcomes in cancer patients (8–11).
Keywords
Breast, Humans, Breast Neoplasms, Hormones, Prospective Studies, Menstrual Cycle, Female, Optics and Photonics
Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Identifiers
External DOI: https://doi.org/10.1055/a-0628-6248
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279390
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