DNA REPAIR. Drugging DNA repair.
Science (New York, N.Y.)
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Jackson, S., & Helleday, T. (2016). DNA REPAIR. Drugging DNA repair.. Science (New York, N.Y.), 352 (6290), 1178-1179. https://doi.org/10.1126/science.aab0958
All the cells in our bodies suffer many thousands of DNA lesions every day (1). The vast majority of these lesions are safely dealt with by cellular DNA repair and associated DNA damage response (DDR) activities that are, as a consequence, vital for life. Defects in or deregulation of our DNA repair/DDR systems are linked to many human pathologies (2). Yet, perhaps counterintuitively, pharmacological inhibitors of DNA repair/DDR have considerable potential in treating various human diseases, particularly cancer.
Humans, Neoplasms, Progeria, DNA Damage, Protein Kinases, Cell Cycle Proteins, BRCA1 Protein, BRCA2 Protein, Nuclear Proteins, Antineoplastic Agents, Protein Kinase Inhibitors, Treatment Outcome, DNA Repair, Protein-Tyrosine Kinases, Ataxia Telangiectasia Mutated Proteins, Checkpoint Kinase 1
Cancer Research UK (18796)
External DOI: https://doi.org/10.1126/science.aab0958
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279420