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dc.contributor.authorMa, Eric Hen
dc.contributor.authorBantug, Glennen
dc.contributor.authorGriss, Taklaen
dc.contributor.authorCondotta, Stephanieen
dc.contributor.authorJohnson, Radia Men
dc.contributor.authorSamborska, Bozenaen
dc.contributor.authorMainolfi, Nelloen
dc.contributor.authorSuri, Vipinen
dc.contributor.authorGuak, Hannahen
dc.contributor.authorBalmer, Maria Len
dc.contributor.authorVerway, Mark Jen
dc.contributor.authorRaissi, Thomas Cen
dc.contributor.authorTsui, Harmonyen
dc.contributor.authorBoukhaled, Giselleen
dc.contributor.authorHenriques da Costa, Sofiaen
dc.contributor.authorFrezza, Christianen
dc.contributor.authorKrawczyk, Connie Men
dc.contributor.authorFriedman, Adamen
dc.contributor.authorManfredi, Marken
dc.contributor.authorRicher, Martin Jen
dc.contributor.authorHess, Christophen
dc.contributor.authorJones, Russell Gen
dc.date.accessioned2018-09-05T12:44:44Z
dc.date.available2018-09-05T12:44:44Z
dc.date.issued2017-02en
dc.identifier.issn1550-4131
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279462
dc.description.abstractDuring immune challenge, T lymphocytes engage pathways of anabolic metabolism to meet the demands of clonal expansion and development of effector functions. Here we report a critical role for the non-essential amino acid serine in effector T cell responses. Upon activation, T cells upregulate enzymes of the serine, glycine, one-carbon (SGOC) metabolic network, and rapidly increase processing of serine into one-carbon metabolism. We show that T cell proliferation is highly dependent on extracellular serine, and that serine is required for optimal T cell expansion even in glucose concentrations sufficient to support T cell activation, bioenergetics, and effector function. Restricting dietary serine impairs pathogen-driven expansion of T cells in vivo, without affecting overall immune cell homeostasis. Mechanistically, we demonstrate that serine supplies glycine and one-carbon units for de novo nucleotide biosynthesis in proliferating T cells, and that one-carbon units from formate can rescue T cells from serine deprivation. Our data implicate serine as a key immunometabolite that directly modulates adaptive immunity by controlling T cell proliferative capacity.
dc.format.mediumPrinten
dc.languageengen
dc.titleSerine Is an Essential Metabolite for Effector T Cell Expansion.en
dc.typeArticle
prism.issueIdentifier2en
prism.publicationDate2017en
prism.publicationNameCell metabolismen
prism.startingPage482
prism.volume25en
dc.identifier.doi10.17863/CAM.26836
dcterms.dateAccepted2016-12-19en
rioxxterms.versionofrecord10.1016/j.cmet.2017.01.014en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-02en
dc.contributor.orcidFrezza, Christian [0000-0002-3293-7397]
dc.identifier.eissn1932-7420
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12022/1_do not transfer?)
rioxxterms.freetoread.startdate2018-02-28


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