Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp(3) )-H Activation.
Angewandte Chemie (International ed. in English)
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Zakrzewski, J., Smalley, A. P., Kabeshov, M., Gaunt, M., & Lapkin, A. (2016). Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp(3) )-H Activation.. Angewandte Chemie (International ed. in English), 55 (31), 8878-8883. https://doi.org/10.1002/anie.201602483
A continuous-flow synthesis of aziridines by palladium-catalyzed C(sp(3) )-H activation is described. The new flow reaction could be combined with an aziridine-ring-opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C-H activation flow process and illustrates an approach towards first-principles design based on novel catalytic reactions.
Engineering and Physical Sciences Research Council (EP/I00548X/1)
External DOI: https://doi.org/10.1002/anie.201602483
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279472
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/