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dc.contributor.authorHolt, Kathryn E
dc.contributor.authorMcAdam, Paul
dc.contributor.authorThai, Phan Vuong Khac
dc.contributor.authorThuong, Nguyen Thuy Thuong
dc.contributor.authorHa, Dang Thi Minh
dc.contributor.authorLan, Nguyen Ngoc
dc.contributor.authorLan, Nguyen Huu
dc.contributor.authorNhu, Nguyen Thi Quynh
dc.contributor.authorHai, Hoang Thanh
dc.contributor.authorHa, Vu Thi Ngoc
dc.contributor.authorThwaites, Guy
dc.contributor.authorEdwards, David J
dc.contributor.authorNath, Artika P
dc.contributor.authorPham, Kym
dc.contributor.authorAscher, David B
dc.contributor.authorFarrar, Jeremy
dc.contributor.authorKhor, Chiea Chuen
dc.contributor.authorTeo, Yik Ying
dc.contributor.authorInouye, Michael
dc.contributor.authorCaws, Maxine
dc.contributor.authorDunstan, Sarah J
dc.date.accessioned2018-09-05T12:47:06Z
dc.date.available2018-09-05T12:47:06Z
dc.date.issued2018-06
dc.identifier.issn1061-4036
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279529
dc.description.abstractTo examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data identify an underlying burden of disease caused by the endemic Mtb lineage 1 associated with the activation of long-term latent infection, and a threefold higher burden associated with the more recently introduced Beijing lineage and lineage 4 Mtb strains. We find that Beijing lineage Mtb is frequently transferred between Vietnam and other countries, and detect higher levels of transmission of Beijing lineage strains within this host population than the endemic lineage 1 Mtb. Screening for parallel evolution of Beijing lineage-associated SNPs in other Mtb lineages as a signal of positive selection, we identify an alteration in the ESX-5 type VII-secreted protein EsxW, which could potentially contribute to the enhanced transmission of Beijing lineage Mtb in Vietnamese and other host populations.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectHumans
dc.subjectMycobacterium tuberculosis
dc.subjectTuberculosis
dc.subjectDNA, Bacterial
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectVietnam
dc.subjectBeijing
dc.titleFrequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.
dc.typeArticle
prism.endingPage856
prism.issueIdentifier6
prism.publicationDate2018
prism.publicationNameNat Genet
prism.startingPage849
prism.volume50
dc.identifier.doi10.17863/CAM.26902
dcterms.dateAccepted2018-03-22
rioxxterms.versionofrecord10.1038/s41588-018-0117-9
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-06
dc.contributor.orcidHolt, Kathryn E [0000-0003-3949-2471]
dc.contributor.orcidKhor, Chiea Chuen [0000-0002-1128-4729]
dc.identifier.eissn1546-1718
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (None)
cam.issuedOnline2018-05-21
rioxxterms.freetoread.startdate2019-06-01


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