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dc.contributor.authorSimon, Alexisen
dc.contributor.authorBierne, Nicolasen
dc.contributor.authorWelch, Johnen
dc.date.accessioned2018-09-05T12:47:23Z
dc.date.available2018-09-05T12:47:23Z
dc.date.issued2018-10en
dc.identifier.issn2056-3744
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279537
dc.description.abstractNatural selection plays a variety of roles in hybridization, speciation and admixture. Most research has focused on two extreme cases: crosses between closely-related inbred lines, where hybrids are fitter than their parents, or crosses between effectively isolated species, where hybrids suffer severe breakdown. But many natural populations must fall into intermediate regimes, with multiple types of gene interaction, and these are more difficult to study. Here, we develop a simple fitness landscape model, and show that it naturally interpolates between previous modeling approaches, which were designed for the extreme cases, and invoke either mildly deleterious recessives, or discrete hybrid incompatibilities. Our model yields several new predictions, which we test with genomic data from Mytilus mussels, and published data from plants (Zea, Populus and Senecio) and animals (Mus, Teleogryllus and Drosophila). The predictions are generally supported, and the model explains a number of surprising empirical patterns. Our approach enables novel and complementary uses of genome-wide datasets, which do not depend on identifying outlier loci, or “speciation genes” with anomalous effects. Given its simplicity and flexibility, and its predictive successes with a wide range of data, the approach should be readily extendable to other outstanding questions in the study of hybridization.
dc.description.sponsorshipAgence Nationale de la Recherché; fellowship of the French Embassy in the United Kingdom, with Churchill 546 College Cambridge; fellowship of the Labex CeMEB and the doctoral school GAIA
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleCoadapted genomes and selection on hybrids: Fisher's geometric model explains a variety of empirical patterns.en
dc.typeArticle
prism.endingPage498
prism.issueIdentifier5en
prism.publicationDate2018en
prism.publicationNameEvolution lettersen
prism.startingPage472
prism.volume2en
dc.identifier.doi10.17863/CAM.26910
dcterms.dateAccepted2018-06-06en
rioxxterms.versionofrecord10.1002/evl3.66en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-10en
dc.contributor.orcidSimon, Alexis [0000-0002-6176-5045]
dc.contributor.orcidBierne, Nicolas [0000-0003-1856-3197]
dc.contributor.orcidWelch, John [0000-0001-7049-7129]
dc.identifier.eissn2056-3744
rioxxterms.typeJournal Article/Reviewen


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)