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dc.contributor.authorGolding, JP
dc.contributor.authorKemp-Symonds, JG
dc.contributor.authorDobson, Jane
dc.date.accessioned2018-09-05T12:48:06Z
dc.date.available2018-09-05T12:48:06Z
dc.date.issued2017-12
dc.identifier.issn1476-5810
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279557
dc.description.abstractPhotodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to lesions thicker than around 2 mm, and by the intrinsic antioxidant defences of tumour cells. We have developed a new PDT technique that combines an efficient transdermal penetration enhancer solution, for topical delivery of 5-aminolevulinic acid (ALA) photosensitiser, with acute topical post-PDT application of the glycolysis inhibitor lonidamine. We show that the new PDT combination treatment selectively kills sarcoid cells in vitro, with repeated rounds of treatment increasing sarcoid sensitisation to PDT. In vivo, ALA PDT followed by 600 μM lonidamine substantially improves treatment outcomes for occult, verrucous, nodular and fibroblastic sarcoids after 1 month (93% treatment response in 27 sarcoids), compared with PDT using only ALA (14% treatment response in 7 sarcoids).
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.subjectCell Line, Tumor
dc.subjectAnimals
dc.subjectHorses
dc.subjectSkin Neoplasms
dc.subjectHorse Diseases
dc.subjectAminolevulinic Acid
dc.subjectPhotosensitizing Agents
dc.subjectPhotochemotherapy
dc.subjectGlycolysis
dc.titleGlycolysis inhibition improves photodynamic therapy response rates for equine sarcoids.
dc.typeArticle
prism.endingPage1552
prism.issueIdentifier4
prism.publicationDate2017
prism.publicationNameVet Comp Oncol
prism.startingPage1543
prism.volume15
dc.identifier.doi10.17863/CAM.26929
dcterms.dateAccepted2016-11-20
rioxxterms.versionofrecord10.1111/vco.12299
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-12
dc.contributor.orcidGolding, JP [0000-0002-7910-7382]
dc.contributor.orcidDobson, Jane [0000-0002-7121-014X]
dc.identifier.eissn1476-5829
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-01-27
rioxxterms.freetoread.startdate2018-12-31


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