Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans.
Damgaard, Peter de Barros
Bazaliiskii, Vladimir I
Jones, Terry C
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
MetadataShow full item record
Mühlemann, B., Margaryan, A., Damgaard, P. d. B., Allentoft, M. E., Vinner, L., Hansen, A. J., Weber, A., et al. (2018). Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans.. Proceedings of the National Academy of Sciences of the United States of America, 115 (29), 7557-7562. https://doi.org/10.1073/pnas.1804921115
Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. Based on genetic sequences up to ~70 years of age, the most recent common ancestor (MRCA) of all B19V has been dated to the early 1800s and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9% to 99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from ~0.5 to ~6.8 thousand years ago (kya). Five ancient B19V sequences fall within or basal to modern genotype 1 and five fall basal to genotype 2, showing a long-term association of B19V with humans. We find a substitution rate of the virus that is an order of magnitude lower than inferred previously. The most recent common ancestor of all B19V is placed ~10.7 kya. Further, we are able to date the recombination event between genotypes 1 and 3 that formed genotype 2 to approximately 5.1 to 6.7 kya. This study presents some of the oldest exogenous viral sequences yet found and emphasizes the importance of ancient viral sequences for our understanding of virus evolution and phylogenetics.
Humans, Parvovirus B19, Human, Erythema Infectiosum, Sequence Analysis, DNA, Evolution, Molecular, Phylogeny, Genotype, Genome, Viral, History, 19th Century, History, 20th Century
European Commission Horizon 2020 (H2020) Societal Challenges (643476)
EC FP7 CP (278976)
External DOI: https://doi.org/10.1073/pnas.1804921115
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279593