Show simple item record

dc.contributor.authorOtal, Begonya
dc.contributor.authorOlma, Manuel C
dc.contributor.authorFlöel, Agnes
dc.contributor.authorWellwood, Ian
dc.date.accessioned2018-09-05T12:50:50Z
dc.date.available2018-09-05T12:50:50Z
dc.date.issued2015
dc.identifier.issn1662-5161
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279632
dc.description.abstractChronic communication impairment is common after stroke, and conventional speech and language therapy (SLT) strategies have limited effectiveness in post-stroke aphasia. Neurorehabilitation with non-invasive brain stimulation techniques (NIBS)-particularly repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS)-may enhance the effects of SLT in selected patients. Applying inhibitory NIBS to specific homologous language regions may induce neural reorganization and reduce interhemispheric competition. This mini review highlights randomized controlled trials (RCTs) and randomized cross-over trials using low-frequency rTMS or cathodal tDCS over the non-lesioned non-language dominant hemisphere and performs an exploratory meta-analysis of those trials considered combinable. Using a random-effects model, a meta-analysis of nine eligible trials involving 215 participants showed a significant mean effect size of 0.51 (95% CI = 0.24-0.79) for the main outcome "accuracy of naming" in language assessment. No heterogeneity was observed (I (2) = 0%). More multicenter RCTs with larger populations and homogenous intervention protocols are required to confirm these and the longer-term effects.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleInhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis.
dc.typeArticle
prism.publicationDate2015
prism.publicationNameFront Hum Neurosci
prism.startingPage236
prism.volume9
dc.identifier.doi10.17863/CAM.27002
dcterms.dateAccepted2015-04-13
rioxxterms.versionofrecord10.3389/fnhum.2015.00236
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-01
dc.contributor.orcidWellwood, Ian [0000-0002-6059-9209]
dc.identifier.eissn1662-5161
rioxxterms.typeJournal Article/Review
cam.issuedOnline2015-04-28


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)