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Antibody Persistence at the Population Level 5 Years After Mass Vaccination With Meningococcal Serogroup A Conjugate Vaccine (PsA-TT) in Burkina Faso: Need for a Booster Campaign?

Accepted version
Peer-reviewed

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Type

Article

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Authors

Yaro, Seydou 
Njanpop Lafourcade, Berthe-Marie 
Ouangraoua, Soumeya 
Ouoba, Aline 
Kpoda, Hervé 

Abstract

BACKGROUND: In Burkina Faso, serogroup A meningococcal (NmA) conjugate vaccine (PsA-TT, MenAfriVac) was introduced through a mass campaign in children and adults in December 2010. Similar to a serological survey in 2011, we followed population-level antibody persistence for 5 years after the campaign and estimated time of return to previously-published pre-vaccination levels. METHODS: We conducted 2 cross-sectional surveys in 2013 and early 2016, including representative samples (N = 600) of the general population of Bobo-Dioulasso, Burkina Faso. Serum bactericidal antibody titers (rabbit complement) were measured against NmA reference strain F8236 (SBA-ref), NmA strain 3125 (SBA-3125), and NmA-specific immunoglobulin G (IgG) concentrations. RESULTS: During the 2016 survey, in different age groups between 6 and 29 years, the relative changes in geometric means compared to 2011 values were greater among younger age groups. They were between -87% and -43% for SBA-ref; -99% and -78% for SBA-3125; and -89% and -63% for IgG. In linear extrapolation of age-specific geometric means from 2013 to 2016, among children aged 1-4 years at the time of the PsA-TT campaign, a return to pre-vaccination levels should be expected after 12, 8, and 6 years, respectively, according to SBA-ref, SBA-3125, and IgG. Among older individuals, complete return to baseline is expected at the earliest after 11 years (SBA-ref and SBA-3125) or 9 years (IgG). CONCLUSIONS: Based on SBA-3125, a booster campaign after 8 years would be required to sustain direct immune protection for children aged 1-4 years during the PsA-TT campaign. Antibodies persisted longer in older age groups.

Description

Keywords

Adolescent, Adult, Animals, Antibodies, Bacterial, Burkina Faso, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Immunoglobulin G, Infant, Male, Mass Vaccination, Meningococcal Infections, Meningococcal Vaccines, Neisseria meningitidis, Serogroup A, Rabbits, Time Factors, Young Adult

Journal Title

Clin Infect Dis

Conference Name

Journal ISSN

1058-4838
1537-6591

Volume Title

68

Publisher

Oxford University Press (OUP)
Sponsorship
Meningitis Research Foundation