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dc.contributor.authorRoeder, Konstantin
dc.contributor.authorWales, David
dc.date.accessioned2018-09-08T06:28:49Z
dc.date.available2018-09-08T06:28:49Z
dc.date.issued2018-12-13
dc.identifier.issn1520-6106
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279738
dc.description.abstractProtein folding is often viewed in terms of a funneled potential or free energy landscape. A variety of experiments now indicate the existence of multifunnel landscapes, associated with multifunctional biomolecules. Here, we present evidence that these systems have evolved to exhibit the minimal number of funnels required to fulfill their cellular functions, suggesting an extension to the principle of minimum frustration. We find that minimal disruptive mutations result in additional funnels, and the associated structural ensembles become more diverse. The same trends are observed in an atomic cluster. These observations suggest guidelines for rational design of engineered multifunctional biomolecules.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherAmerican Chemical Society (ACS)
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectProteins
dc.subjectProtein Engineering
dc.subjectProtein Folding
dc.subjectMutation
dc.subjectThermodynamics
dc.titleEvolved Minimal Frustration in Multifunctional Biomolecules.
dc.typeArticle
prism.endingPage10995
prism.issueIdentifier49
prism.publicationDate2018
prism.publicationNameJ Phys Chem B
prism.startingPage10989
prism.volume122
dc.identifier.doi10.17863/CAM.27109
dcterms.dateAccepted2018-05-25
rioxxterms.versionofrecord10.1021/acs.jpcb.8b03632
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-12
dc.contributor.orcidRoeder, Konstantin [0000-0003-2021-9504]
dc.contributor.orcidWales, David [0000-0002-3555-6645]
dc.identifier.eissn1520-5207
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEPSRC (1652488)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/N035003/1)
cam.issuedOnline2018-05-25


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)