Classic Models for New Perspectives: Delving into Helminth-Microbiota-Immune System Interactions.
dc.contributor.author | Cortés, Alba | |
dc.contributor.author | Toledo, Rafael | |
dc.contributor.author | Cantacessi, Cinzia | |
dc.date.accessioned | 2018-09-08T06:29:07Z | |
dc.date.available | 2018-09-08T06:29:07Z | |
dc.date.issued | 2018-08 | |
dc.identifier.issn | 1471-4922 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/279747 | |
dc.description.abstract | Whilst a wealth of data indicate that infections by gastrointestinal helminths are accompanied by significant alterations in the composition of the vertebrate gut flora, little is known of the immune-molecular mechanisms that regulate host-parasite-microbiota interactions. 'Traditional' experimental models of gastrointestinal helminthiases, in which the role(s) of each of the components of this triad can be tested, provide an opportunity to advance research in this area. In this article, we propose the Echinostoma caproni-mouse system as a potentially useful tool for studies of the role of the host gut microbiota in preventing pathology and inducing parasite clearance via interleukin (IL)-25, an epithelial-derived alarmin with key roles in antihelminth immunity and maintenance of gut homeostasis. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | Elsevier BV | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Helminthiasis | |
dc.subject | Models, Biological | |
dc.subject | Host-Parasite Interactions | |
dc.title | Classic Models for New Perspectives: Delving into Helminth-Microbiota-Immune System Interactions. | |
dc.type | Article | |
prism.endingPage | 654 | |
prism.issueIdentifier | 8 | |
prism.publicationDate | 2018 | |
prism.publicationName | Trends Parasitol | |
prism.startingPage | 640 | |
prism.volume | 34 | |
dc.identifier.doi | 10.17863/CAM.27117 | |
dcterms.dateAccepted | 2018-05-31 | |
rioxxterms.versionofrecord | 10.1016/j.pt.2018.05.009 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2018-08 | |
dc.contributor.orcid | Cantacessi, Cinzia [0000-0001-6863-2950] | |
dc.identifier.eissn | 1471-5007 | |
rioxxterms.type | Journal Article/Review | |
cam.issuedOnline | 2018-06-22 | |
rioxxterms.freetoread.startdate | 2019-08-31 |
Files in this item
This item appears in the following Collection(s)
-
Cambridge University Research Outputs
Research outputs of the University of Cambridge