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dc.contributor.authorCortés, Alba
dc.contributor.authorToledo, Rafael
dc.contributor.authorCantacessi, Cinzia
dc.date.accessioned2018-09-08T06:29:07Z
dc.date.available2018-09-08T06:29:07Z
dc.date.issued2018-08
dc.identifier.issn1471-4922
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279747
dc.description.abstractWhilst a wealth of data indicate that infections by gastrointestinal helminths are accompanied by significant alterations in the composition of the vertebrate gut flora, little is known of the immune-molecular mechanisms that regulate host-parasite-microbiota interactions. 'Traditional' experimental models of gastrointestinal helminthiases, in which the role(s) of each of the components of this triad can be tested, provide an opportunity to advance research in this area. In this article, we propose the Echinostoma caproni-mouse system as a potentially useful tool for studies of the role of the host gut microbiota in preventing pathology and inducing parasite clearance via interleukin (IL)-25, an epithelial-derived alarmin with key roles in antihelminth immunity and maintenance of gut homeostasis.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.subjectAnimals
dc.subjectHumans
dc.subjectHelminthiasis
dc.subjectModels, Biological
dc.subjectHost-Parasite Interactions
dc.titleClassic Models for New Perspectives: Delving into Helminth-Microbiota-Immune System Interactions.
dc.typeArticle
prism.endingPage654
prism.issueIdentifier8
prism.publicationDate2018
prism.publicationNameTrends Parasitol
prism.startingPage640
prism.volume34
dc.identifier.doi10.17863/CAM.27117
dcterms.dateAccepted2018-05-31
rioxxterms.versionofrecord10.1016/j.pt.2018.05.009
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
dc.identifier.eissn1471-5007
rioxxterms.typeJournal Article/Review
rioxxterms.freetoread.startdate2019-08-31


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