A Network Neuroscience Approach to Typical and Atypical Brain Development.
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Authors
Morgan, Sarah E
White, Simon R
Bullmore, Edward T
Vértes, Petra E
Publication Date
2018-09Journal Title
Biol Psychiatry Cogn Neurosci Neuroimaging
ISSN
2451-9022
Publisher
Elsevier BV
Volume
3
Issue
9
Pages
754-766
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Morgan, S. E., White, S. R., Bullmore, E. T., & Vértes, P. E. (2018). A Network Neuroscience Approach to Typical and Atypical Brain Development.. Biol Psychiatry Cogn Neurosci Neuroimaging, 3 (9), 754-766. https://doi.org/10.1016/j.bpsc.2018.03.003
Abstract
Human brain networks based on neuroimaging data have already proven useful in characterizing both normal and abnormal brain structure and function. However, many brain disorders are neurodevelopmental in origin, highlighting the need to go beyond characterizing brain organization in terms of static networks. Here, we review the fast-growing literature shedding light on developmental changes in network phenotypes. We begin with an overview of recent large-scale efforts to map healthy brain development, and we describe the key role played by longitudinal data including repeated measurements over a long period of follow-up. We also discuss the subtle ways in which healthy brain network development can inform our understanding of disorders, including work bridging the gap between macroscopic neuroimaging results and the microscopic level. Finally, we turn to studies of three specific neurodevelopmental disorders that first manifest primarily in childhood and adolescence/early adulthood, namely psychotic disorders, attention-deficit/hyperactivity disorder, and autism spectrum disorder. In each case we discuss recent progress in understanding the atypical features of brain network development associated with the disorder, and we conclude the review with some suggestions for future directions.
Keywords
ADHD, Autism spectrum disorder, Development, MRI, Network neuroscience, Schizophrenia, Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorder, Brain, Humans, Nerve Net, Neuroimaging, Neurosciences, Schizophrenia
Sponsorship
European Commission (603196)
MRC (1185)
MRC (unknown)
Medical Research Council (G1000183)
Medical Research Council (MR/K020706/1)
Medical Research Council (G0001354)
MQ: Transforming Mental Health (MQ17-24 Vertes)
Identifiers
External DOI: https://doi.org/10.1016/j.bpsc.2018.03.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279813
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http://www.rioxx.net/licenses/all-rights-reserved
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