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dc.contributor.authorShahbazi, Marta N
dc.contributor.authorZernicka-Goetz, Magdalena
dc.date.accessioned2018-09-08T06:31:39Z
dc.date.available2018-09-08T06:31:39Z
dc.date.issued2018-08
dc.identifier.issn1465-7392
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279825
dc.description.abstractThe emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.
dc.description.sponsorshipEuropean Research Council (669198) Wellcome Trust (098287/Z/12/Z) Early Career Leverhulme Trust fellowship.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectCells, Cultured
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectEmbryo Research
dc.subjectSignal Transduction
dc.subjectGene Expression Regulation, Developmental
dc.subjectCell Lineage
dc.subjectMorphogenesis
dc.subjectGestational Age
dc.subjectHistory, 20th Century
dc.subjectHistory, 21st Century
dc.subjectEmbryo, Mammalian
dc.subjectStem Cell Research
dc.subjectHuman Embryonic Stem Cells
dc.subjectMouse Embryonic Stem Cells
dc.titleDeconstructing and reconstructing the mouse and human early embryo.
dc.typeArticle
prism.endingPage887
prism.issueIdentifier8
prism.publicationDate2018
prism.publicationNameNat Cell Biol
prism.startingPage878
prism.volume20
dc.identifier.doi10.17863/CAM.27195
dcterms.dateAccepted2018-06-15
rioxxterms.versionofrecord10.1038/s41556-018-0144-x
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidShahbazi, Marta N [0000-0002-1599-5747]
dc.contributor.orcidZernicka-Goetz, Magdalena [0000-0002-7004-2471]
dc.identifier.eissn1476-4679
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (098287/Z/12/Z)
pubs.funder-project-idEuropean Research Council (669198)
pubs.funder-project-idIsaac Newton Trust (17.08(p))
pubs.funder-project-idLeverhulme Trust (ECF-2017-285)
cam.issuedOnline2018-07-23
rioxxterms.freetoread.startdate2019-01-23


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