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dc.contributor.authorHowe, Kerstin
dc.contributor.authorSchiffer, Philipp H
dc.contributor.authorZielinski, Julia
dc.contributor.authorWiehe, Thomas
dc.contributor.authorLaird, Gavin K
dc.contributor.authorMarioni, John
dc.contributor.authorSoylemez, Onuralp
dc.contributor.authorKondrashov, Fyodor
dc.contributor.authorLeptin, Maria
dc.date.accessioned2018-09-08T06:33:38Z
dc.date.available2018-09-08T06:33:38Z
dc.date.issued2016-04
dc.identifier.issn2046-2441
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279887
dc.description.abstractMulticellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins. Mammals have small numbers of NLR proteins, whereas in some species, mostly those without adaptive immune systems, NLRs have expanded into very large families. We describe a family of nearly 400 NLR proteins encoded in the zebrafish genome. The proteins share a defining overall structure, which arose in fishes after a fusion of the core NLR domains with a B30.2 domain, but can be subdivided into four groups based on their NACHT domains. Gene conversion acting differentially on the NACHT and B30.2 domains has shaped the family and created the groups. Evidence of positive selection in the B30.2 domain indicates that this domain rather than the leucine-rich repeats acts as the pathogen recognition module. In an unusual chromosomal organization, the majority of the genes are located on one chromosome arm, interspersed with other large multigene families, including a new family encoding zinc-finger proteins. The NLR-B30.2 proteins represent a new family with diversity in the specific recognition module that is present in fishes in spite of the parallel existence of an adaptive immune system.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherThe Royal Society
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectZebrafish
dc.subjectZebrafish Proteins
dc.subjectEvolution, Molecular
dc.subjectAmino Acid Sequence
dc.subjectConserved Sequence
dc.subjectMultigene Family
dc.subjectGenome
dc.subjectTime Factors
dc.subjectProtein Domains
dc.subjectNLR Proteins
dc.titleStructure and evolutionary history of a large family of NLR proteins in the zebrafish.
dc.typeArticle
prism.issueIdentifier4
prism.publicationDate2016
prism.publicationNameOpen Biol
prism.startingPage160009
prism.volume6
dc.identifier.doi10.17863/CAM.27255
dcterms.dateAccepted2016-04-05
rioxxterms.versionofrecord10.1098/rsob.160009
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-04-27
dc.contributor.orcidHowe, Kerstin [0000-0003-2237-513X]
dc.contributor.orcidSchiffer, Philipp H [0000-0001-6776-0934]
dc.contributor.orcidWiehe, Thomas [0000-0002-8932-2772]
dc.contributor.orcidLaird, Gavin K [0000-0003-2294-0135]
dc.contributor.orcidMarioni, John [0000-0001-9092-0852]
dc.contributor.orcidSoylemez, Onuralp [0000-0001-8308-6855]
dc.contributor.orcidLeptin, Maria [0000-0001-7097-348X]
dc.identifier.eissn2046-2441
rioxxterms.typeJournal Article/Review
cam.issuedOnline2016-04


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)