Prediction of GABARAP interaction with the GABA type A receptor.
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Irwin, B., Vukovič, S., Payne, M., ElGamacy, M., & Chau, P. (2018). Prediction of GABARAP interaction with the GABA type A receptor.. Proteins, 86 (12), 1251-1264. https://doi.org/10.1002/prot.25589
We have performed docking simulations on GABARAP interacting with the GABA type A receptor using SwarmDock. We have also used a novel method to study hydration sites on the surface of these two proteins; this method identifies regions around proteins where desolvation is relatively easy, and these are possible locations where proteins can bind each other. There is a high degree of consistency between the predictions of these two methods. Moreover, we have also identified binding sites on GABARAP for other proteins, and listed possible binding sites for as yet unknown proteins on both GABARAP and the GABA type A receptor intracellular domain.
Humans, Adaptor Proteins, Signal Transducing, Microtubule-Associated Proteins, Receptors, GABA-A, Binding Sites, Protein Conformation, Thermodynamics, Databases, Protein, Apoptosis Regulatory Proteins, Protein Multimerization, Molecular Docking Simulation
Engineering and Physical Sciences Research Council (EP/L015552/1)
Medical Research Council (MR/L007266/1)
Engineering and Physical Sciences Research Council (EP/P034616/1)
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External DOI: https://doi.org/10.1002/prot.25589
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279902
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/