Planar cell polarity: the prickle gene acts independently on both the Ds/Ft and the Stan/Fz systems
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Publication Date
2018-09-17Journal Title
Development
ISSN
0950-1991
Publisher
The Company of Biologists
Volume
145
Issue
8
Pages
1-1
Type
Article
Metadata
Show full item recordCitation
Casal Jimenez, J., Ibáñez-Jiménez, B., & Lawrence, P. (2018). Planar cell polarity: the prickle gene acts independently on both the Ds/Ft and the Stan/Fz systems. Development, 145 (8), 1-1. https://doi.org/10.1242/dev.168112
Abstract
Epithelial cells are polarised within the plane of the epithelium, forming oriented structures whose coordinated and consistent polarity (planar cell polarity, PCP) relates to the principal axes of the body or organ. In Drosophila at least two separate molecular systems generate and interpret intercellular polarity signals: Dachsous/Fat, and the “core” or Stan/Fz system. Here we study the prickle gene and its protein products Prickle and Spiny leg. Much research on PCP has focused on the asymmetric localisation of core proteins in the cell and as a result prickle was placed in the heart of the Stan/Fz system. Here we ask if this view is correct and how the prickle gene relates to the two systems. We find that prickle can affect, separately, both systems — however, neither Pk nor Sple are essential components of the Ds/Ft or the Stan/Fz system, nor do they act as a functional link between the two systems.
Sponsorship
Wellcome Trust (107060/Z/15/Z)
Wellcome Trust (096645/Z/11/Z)
Identifiers
External DOI: https://doi.org/10.1242/dev.168112
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279909
Rights
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/
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