Show simple item record

dc.contributor.authorCasal Jimenez, Jose
dc.contributor.authorIbáñez-Jiménez, Beatriz
dc.contributor.authorLawrence, Peter
dc.date.accessioned2018-09-08T06:34:21Z
dc.date.available2018-09-08T06:34:21Z
dc.date.issued2018-09-17
dc.identifier.issn0950-1991
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279909
dc.description.abstractEpithelial cells are polarised within the plane of the epithelium, forming oriented structures whose coordinated and consistent polarity (planar cell polarity, PCP) relates to the principal axes of the body or organ. In Drosophila at least two separate molecular systems generate and interpret intercellular polarity signals: Dachsous/Fat, and the “core” or Stan/Fz system. Here we study the prickle gene and its protein products Prickle and Spiny leg. Much research on PCP has focused on the asymmetric localisation of core proteins in the cell and as a result prickle was placed in the heart of the Stan/Fz system. Here we ask if this view is correct and how the prickle gene relates to the two systems. We find that prickle can affect, separately, both systems — however, neither Pk nor Sple are essential components of the Ds/Ft or the Stan/Fz system, nor do they act as a functional link between the two systems.
dc.publisherThe Company of Biologists
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titlePlanar cell polarity: the prickle gene acts independently on both the Ds/Ft and the Stan/Fz systems
dc.typeArticle
prism.endingPage1
prism.issueIdentifier8
prism.publicationDate2018
prism.publicationNameDevelopment
prism.startingPage1
prism.volume145
dc.identifier.doi10.17863/CAM.27277
dcterms.dateAccepted2018-08-08
rioxxterms.versionofrecord10.1242/dev.168112
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09-17
dc.contributor.orcidCasal Jimenez, Jose [0000-0002-5149-1335]
dc.contributor.orcidLawrence, Peter [0000-0002-9554-8268]
dc.identifier.eissn1477-9129
dc.publisher.urlhttps://www.ncbi.nlm.nih.gov/pubmed/30154173
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (107060/Z/15/Z)
pubs.funder-project-idWellcome Trust (096645/Z/11/Z)
cam.issuedOnline2018-01-01
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pubmed/30154173


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)