Show simple item record

dc.contributor.authorPotter, MDEen
dc.contributor.authorWalker, MMen
dc.contributor.authorHancock, Sen
dc.contributor.authorHolliday, Een
dc.contributor.authorBrogan, Gen
dc.contributor.authorJones, Men
dc.contributor.authorMcEvoy, Men
dc.contributor.authorBoyle, Men
dc.contributor.authorTalley, NJen
dc.contributor.authorAttia, Jen
dc.date.accessioned2018-09-08T06:35:00Z
dc.date.available2018-09-08T06:35:00Z
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279930
dc.description.abstractPreviously thought to be mainly a disorder of childhood and early adult life, coeliac disease (CeD) is increasingly diagnosed in older adults. This may be important given the association between CeD and osteoporosis. The primary aim of this study was to determine the seroprevalence of undiagnosed CeD (‘at-risk serology’) in an older Australian community and relate this to a diagnosis of osteoporosis and fractures during a follow-up period of 12 years. We included participants from the Hunter Community Study (2004–2007) aged 55–85, who had anti-tissue transglutaminase (tTG) titres, human leukocyte antigen (HLA) genotypes, and bone mineral density measurements at baseline. Follow-up data included subsequent diagnosis of CeD and fractures using hospital information. ‘At-risk’ serology was defined as both tTG and HLA positivity. Complete results were obtained from 2122 patients. The prevalence of ‘at-risk’ serology was 5%. At baseline, 3.4% fulfilled criteria for a diagnosis of osteoporosis. During a mean of 9.7 years of follow-up, 7.4% of the cohort suffered at least one fracture and 0.7% were subsequently diagnosed with CeD. At-risk serology was significantly associated with osteoporosis in a multivariate model (odds ratio 2.83, 95% confidence interval 1.29–6.22); there was insufficient power to look at the outcome of fractures. The results of this study demonstrate that at-risk CeD serology was significantly associated with concurrent osteoporosis but not future fractures. Most individuals with a serological diagnosis of CeD were not diagnosed with CeD during the follow-up period according to medical records. Coeliac disease likely remains under-diagnosed.
dc.description.sponsorshipThe study was funded by the University of Newcastle, the Hunter Medical Research Institute, and the Vincent Fairfax Family Foundation
dc.publisherMDPI
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA serological diagnosis of coeliac disease is associated with osteoporosis in older Australian adultsen
dc.typeArticle
prism.issueIdentifier7en
prism.number849en
prism.publicationNameNutrientsen
prism.volume10en
dc.identifier.doi10.17863/CAM.27298
dcterms.dateAccepted2018-06-26en
rioxxterms.versionofrecord10.3390/nu10070849en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-06-26en
dc.identifier.eissn2072-6643
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2018-06-29en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)