Acceptability, Accuracy, and Safety of Disposable Transnasal Capsule Endoscopy for Barrett's Esophagus Screening.
Sami, Sarmed S
Iyer, Prasad G
White, Jonathan R
Guha, Indra Neil
Clin Gastroenterol Hepatol
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Sami, S. S., Iyer, P. G., Pophali, P., Halland, M., Di Pietro, M., Ortiz-Fernandez-Sordo, J., White, J. R., et al. (2019). Acceptability, Accuracy, and Safety of Disposable Transnasal Capsule Endoscopy for Barrett's Esophagus Screening.. Clin Gastroenterol Hepatol, 17 (4), 638-646.e1. https://doi.org/10.1016/j.cgh.2018.07.019
BACKGROUND & AIMS: Screening for Barrett's esophagus (BE) with conventional esophagogastroduodenoscopy (C-EGD) is expensive. We assessed the performance of a clinic-based, single use transnasal capsule endoscope (EG Scan II) for the detection of BE, compared to C-EGD as the reference standard. METHODS: We performed a prospective multicenter cohort study of patients with and without BE recruited from 3 referral centers (1 in the United States and 2 in the United Kingdom). Of 200 consenting participants, 178 (89%) completed both procedures (11% failed EG Scan due to the inability to intubate the nasopharynx). The mean age of participants was 57.9 years and 67% were male. The prevalence of BE was 53%. All subjects underwent the 2 procedures on the same day, performed by blinded endoscopists. Patients completed preference and validated tolerability (10-point visual analogue scale [VAS]) questionnaires within 14 days of the procedures. RESULTS: A higher proportion of patients preferred the EG Scan (54.2%) vs the C-EGD (16.7%) (P < .001) and the EG Scan had a higher VAS score (7.2) vs the C-EGD (6.4) (P = .0004). No serious adverse events occurred. The EG Scan identified any length BE with a sensitivity value of 0.90 (95% CI, 0.83-0.96) and a specificity value of 0.91 (95% CI, 0.82-0.96). The EG Scan identified long segment BE with a sensitivity value of 0.95 and short segment BE with a sensitivity values of 0.87. CONCLUSIONS: In a prospective study, we found the EG Scan to be safe and to detect BE with higher than 90% sensitivity and specificity. A higher proportion of patients preferred the EG Scan to C-EGD. This device might be used as a clinic-based tool to screen populations at risk for BE. ISRCTN registry identifier: 70595405; ClinicalTrials.gov no: NCT02066233.
Humans, Barrett Esophagus, Mass Screening, Sensitivity and Specificity, Prospective Studies, Adult, Aged, Aged, 80 and over, Middle Aged, Patient Acceptance of Health Care, United States, Female, Male, Capsule Endoscopy, Patient Safety, United Kingdom
Cancer Research UK (C14478/A12088)
Medical Research Council (MC_UU_12022/2)
External DOI: https://doi.org/10.1016/j.cgh.2018.07.019
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279943
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/