Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality.
View / Open Files
Authors
Luben, Robert
Dalzell, Nichola
Moore, Stephanie
Hogervorst, Eef
Matthews, Fiona E
Wareham, Nick
Brayne, Carol
Khaw, Kay-Tee
Publication Date
2018-11Journal Title
Eur J Epidemiol
ISSN
0393-2990
Publisher
Springer Science and Business Media LLC
Volume
33
Issue
11
Pages
1049-1062
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Hayat, S. A., Luben, R., Dalzell, N., Moore, S., Hogervorst, E., Matthews, F. E., Wareham, N., et al. (2018). Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality.. Eur J Epidemiol, 33 (11), 1049-1062. https://doi.org/10.1007/s10654-018-0439-z
Abstract
Despite several studies demonstrating an independent and inverse association between cognition and mortality, the nature of this association still remains unclear. To examine the association of cognition and mortality after accounting for sociodemographic, health and lifestyle factors and to explore both test and population characteristics influencing this relationship. In a population based cohort of 8585 men and women aged 48-92 years, who had cognitive assessments in 2006-2011 and were followed up till 2016 for mortality, we examined the relationship between individual cognitive tests as well as a global cognition score to compare their ability in predicting mortality and whether these differed by population characteristics. Risk of death was estimated using Cox proportional hazard regression models including sociodemographic, lifestyle and health variables, and self-reported comorbidities, as covariates in the models. Poor cognitive performance (bottom quartile of combined cognition score) was associated with higher risk of mortality, Hazard Ratio = 1.32 (95% Confidence Interval 1.09, 1.60); individual cognitive tests varied in their mortality associations and also performed differently in middle-age and older age groups. Poor cognitive performance is independently associated with higher mortality. This association is observed for global cognition and for specific cognitive abilities. Associations vary depending on the cognitive test (and domain) as well as population characteristics, namely age and education.
Keywords
Humans, Mortality, Risk, Cohort Studies, Cognition, Cognition Disorders, Aging, Aged, Aged, 80 and over, Middle Aged, Female, Male, Cognitive Aging, United Kingdom
Sponsorship
This work was supported by the Medical Research Council, UK http://www.mrc.ac.uk/ (Ref: G0401527) and Cancer Research UK http://www.cancerresearchuk. org/ (CRUK, Ref: C864/A8257). The clinic for EPIC- Norfolk 3 was funded by Research into Ageing, now known as Age UK http://www.ageuk.org.uk/ (Grant Ref: 262). The pilot phase was supported by MRC (Ref: G9502233) and CRUK (Ref: C864/ A2883). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funder references
Medical Research Council (G1000143)
Medical Research Council (MR/N003284/1)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Medical Research Council (G0401527)
Medical Research Council (MC_UU_12015/1)
Cancer Research Uk (None)
Cancer Research Uk (None)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1007/s10654-018-0439-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279964
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.