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dc.contributor.authorHayat, Shabinaen
dc.contributor.authorLuben, Roberten
dc.contributor.authorDalzell, Nicholaen
dc.contributor.authorMoore, Stephanieen
dc.contributor.authorHogervorst, Eefen
dc.contributor.authorMatthews, Fionaen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorBrayne, Carolen
dc.contributor.authorKhaw, Kay-Teeen
dc.date.accessioned2018-09-08T06:36:07Z
dc.date.available2018-09-08T06:36:07Z
dc.date.issued2018-11en
dc.identifier.issn0393-2990
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279964
dc.description.abstractBackground: Despite several studies demonstrating an independent and inverse association between cognition and mortality, the nature of this association still remains unclear. Objectives: To examine the association of cognition and mortality after accounting for sociodemographic, health and lifestyle factors and to explore both test and population characteristics influencing this relationship. Methods: In a population based cohort of 8585 men and women aged 48-92 years, who had cognitive assessments in 2006-11 and were followed up till 2016 for mortality, we examined the relationship between individual cognitive tests as well as a global cognition score to compare their ability in predicting mortality and whether these differed by population characteristics. Risk of death was estimated using Cox proportional hazard regression models including sociodemographic, lifestyle and health variables, and self-reported comorbidities, as covariates in the models. Results: Poor cognitive performance (bottom quartile of combined cognition score) was associated with higher risk of mortality, Hazard Ratio= 1.32 (95% Confidence Interval 1.09, 1.60); individual cognitive tests varied in their mortality associations and also performed differently in middle-age and older age groups. Conclusion: Poor cognitive performance is independently associated with higher mortality. This association is observed for global cognition and for specific cognitive abilities. Associations vary depending on the cognitive test (and domain) as well as population characteristics, namely age and education.
dc.description.sponsorshipThis work was supported by the Medical Research Council, UK http://www.mrc.ac.uk/ (Ref: G0401527) and Cancer Research UK http://www.cancerresearchuk. org/ (CRUK, Ref: C864/A8257). The clinic for EPIC- Norfolk 3 was funded by Research into Ageing, now known as Age UK http://www.ageuk.org.uk/ (Grant Ref: 262). The pilot phase was supported by MRC (Ref: G9502233) and CRUK (Ref: C864/ A2883). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumansen
dc.subjectMortalityen
dc.subjectRisken
dc.subjectCohort Studiesen
dc.subjectCognitionen
dc.subjectCognition Disordersen
dc.subjectAgingen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectCognitive Agingen
dc.subjectUnited Kingdomen
dc.titleUnderstanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality.en
dc.typeArticle
prism.endingPage1062
prism.issueIdentifier11en
prism.publicationDate2018en
prism.publicationNameEuropean journal of epidemiologyen
prism.startingPage1049
prism.volume33en
dc.identifier.doi10.17863/CAM.27332
dcterms.dateAccepted2018-08-29en
rioxxterms.versionofrecord10.1007/s10654-018-0439-zen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-11en
dc.contributor.orcidHayat, Shabina [0000-0001-9068-8723]
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.contributor.orcidMatthews, Fiona [0000-0002-1728-2388]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidBrayne, Carol [0000-0001-5307-663X]
dc.identifier.eissn1573-7284
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/N003284/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idCancer Research UK (A8257)
cam.orpheus.successThu Jan 30 10:54:29 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International