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dc.contributor.authorZannone, Sara
dc.contributor.authorBrzosko, Zuzanna
dc.contributor.authorPaulsen, Ole
dc.contributor.authorClopath, Claudia
dc.date.accessioned2018-09-10T22:17:25Z
dc.date.available2018-09-10T22:17:25Z
dc.date.issued2018-06-21
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280076
dc.description.abstractNeuromodulation plays a fundamental role in the acquisition of new behaviours. In previous experimental work, we showed that acetylcholine biases hippocampal synaptic plasticity towards depression, and the subsequent application of dopamine can retroactively convert depression into potentiation. We also demonstrated that incorporating this sequentially neuromodulated Spike-Timing-Dependent Plasticity (STDP) rule in a network model of navigation yields effective learning of changing reward locations. Here, we employ computational modelling to further characterize the effects of cholinergic depression on behaviour. We find that acetylcholine, by allowing learning from negative outcomes, enhances exploration over the action space. We show that this results in a variety of effects, depending on the structure of the model, the environment and the task. Interestingly, sequentially neuromodulated STDP also yields flexible learning, surpassing the performance of other reward-modulated plasticity rules.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectAcetylcholine
dc.subjectExploratory Behavior
dc.subjectReward
dc.subjectNeuronal Plasticity
dc.subjectModels, Neurological
dc.subjectCholinergic Neurons
dc.subjectSpatial Navigation
dc.titleAcetylcholine-modulated plasticity in reward-driven navigation: a computational study.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage9486
prism.volume8
dc.identifier.doi10.17863/CAM.27440
dcterms.dateAccepted2018-05-29
rioxxterms.versionofrecord10.1038/s41598-018-27393-2
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-06-21
dc.contributor.orcidZannone, Sara [0000-0002-7189-2435]
dc.contributor.orcidPaulsen, Ole [0000-0002-2258-5455]
dc.contributor.orcidClopath, Claudia [0000-0003-4507-8648]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/P019560/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/N019008/1)
cam.issuedOnline2018-06-21


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)