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dc.contributor.authorLawson, Rebecca
dc.contributor.authorMathys, Christoph
dc.contributor.authorRees, Geraint
dc.date.accessioned2018-09-10T22:17:29Z
dc.date.available2018-09-10T22:17:29Z
dc.date.issued2017-09
dc.identifier.issn1097-6256
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280078
dc.description.abstractInsistence on sameness and intolerance of change are among the diagnostic criteria for autism spectrum disorder (ASD), but little research has addressed how people with ASD represent and respond to environmental change. Here, behavioral and pupillometric measurements indicated that adults with ASD are less surprised than neurotypical adults when their expectations are violated, and decreased surprise is predictive of greater symptom severity. A hierarchical Bayesian model of learning suggested that in ASD, a tendency to overlearn about volatility in the face of environmental change drives a corresponding reduction in learning about probabilistically aberrant events, thus putatively rendering these events less surprising. Participant-specific modeled estimates of surprise about environmental conditions were linked to pupil size in the ASD group, thus suggesting heightened noradrenergic responsivity in line with compromised neural gain. This study offers insights into the behavioral, algorithmic and physiological mechanisms underlying responses to environmental volatility in ASD.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.titleAdults with autism overestimate the volatility of the sensory environment.
dc.typeArticle
prism.issueIdentifier9
prism.publicationDate2017
prism.publicationNameNat Neurosci
prism.volume20
dc.identifier.doi10.17863/CAM.27442
dcterms.dateAccepted2017-07-04
rioxxterms.versionofrecord10.1038/nn.4615
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-09-01
dc.contributor.orcidLawson, Rebecca [0000-0003-1228-1244]
dc.contributor.orcidRees, Geraint [0000-0002-9623-7007]
dc.identifier.eissn1546-1726
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-07-31
rioxxterms.freetoread.startdate2018-09-30


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