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dc.contributor.authorJeon, Hyon Jin
dc.contributor.authorPak, Gi Deok
dc.contributor.authorIm, Justin
dc.contributor.authorOwusu-Dabo, Ellis
dc.contributor.authorAdu-Sarkodie, Yaw
dc.contributor.authorGassama Sow, Amy
dc.contributor.authorBassiahi Soura, Abdramane
dc.contributor.authorGasmelseed, Nagla
dc.contributor.authorKeddy, Karen H
dc.contributor.authorBjerregaard-Andersen, Morten
dc.contributor.authorKonings, Frank
dc.contributor.authorAseffa, Abraham
dc.contributor.authorCrump, John A
dc.contributor.authorChon, Yun
dc.contributor.authorBreiman, Robert F
dc.contributor.authorPark, Se Eun
dc.contributor.authorCruz Espinoza, Ligia Maria
dc.contributor.authorSeo, Hye Jin
dc.contributor.authorMay, Jürgen
dc.contributor.authorMeyer, Christian G
dc.contributor.authorAndrews, Jason R
dc.contributor.authorPanzner, Ursula
dc.contributor.authorvon Kalckreuth, Vera
dc.contributor.authorWierzba, Thomas F
dc.contributor.authorRakotozandrindrainy, Raphaël
dc.contributor.authorDougan, Gordon
dc.contributor.authorLevine, Myron M
dc.contributor.authorHombach, Joachim
dc.contributor.authorKim, Jerome H
dc.contributor.authorClemens, John D
dc.contributor.authorBaker, Stephen
dc.contributor.authorMarks, Florian
dc.date.accessioned2018-09-10T22:17:59Z
dc.date.available2018-09-10T22:17:59Z
dc.date.issued2018-11-28
dc.identifier.issn1058-4838
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280093
dc.description.abstractBACKGROUND: The World Health Organization recently prequalified a typhoid conjugate vaccine (TCV), recommending its use in persons ≥6 months to 45 years residing in typhoid fever (TF)-endemic areas. We now need to consider how TCVs can have the greatest impact in the most vulnerable populations. METHODS: The Typhoid Fever Surveillance in Africa Program (TSAP) was a blood culture-based surveillance of febrile patients from defined populations presenting at healthcare facilities in 10 African countries. TF and invasive non-typhoidal Salmonella (iNTS) disease incidences were estimated for 0-10 year-olds in one-year age increments. RESULTS: Salmonella Typhi and iNTS were the most frequently isolated pathogens; 135 and 94 cases were identified, respectively. Analysis from three countries was excluded (incomplete person-years of observation (PYO) data). Thirty-seven of 123 TF cases (30.1%) and 71/90 iNTS disease cases (78.9%) occurred in children aged <5 years. No TF and 8/90 iNTS infections (8.9%) were observed in infants aged <9 months. The TF incidences (/100 000 PYO) for children aged <1 year and 1 to <2 years were 5 and 39, respectively; the highest incidence was 304 per 100 000 PYO in 4 to <5 year-olds. The iNTS disease incidence in the defined age groups ranged between 81 and 233 per 100 000 PYO, highest in 1 to <2 year-olds. TF and iNTS disease incidences were higher in West Africa. CONCLUSIONS: High burden of TF detected in young children strengthens the need for TCV introduction. Given the concurrent iNTS disease burden, development of a trivalent vaccine against S. Typhi, S. Typhimurium, and S. Enteritidis may be timely in this region.
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectSalmonella
dc.subjectSalmonella typhi
dc.subjectSalmonella Infections
dc.subjectFever
dc.subjectTyphoid-Paratyphoid Vaccines
dc.subjectVaccines, Conjugate
dc.subjectIncidence
dc.subjectCost of Illness
dc.subjectAdolescent
dc.subjectAdult
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectAfrica South of the Sahara
dc.subjectYoung Adult
dc.subjectEpidemiological Monitoring
dc.titleDetermining the Best Immunization Strategy for Protecting African Children Against Invasive Salmonella Disease.
dc.typeArticle
prism.endingPage1830
prism.issueIdentifier12
prism.publicationDate2018
prism.publicationNameClin Infect Dis
prism.startingPage1824
prism.volume67
dc.identifier.doi10.17863/CAM.27457
dcterms.dateAccepted2018-04-27
rioxxterms.versionofrecord10.1093/cid/ciy386
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11
dc.contributor.orcidDougan, Gordon [0000-0003-0022-965X]
dc.contributor.orcidBaker, Stephen [0000-0003-1308-5755]
dc.contributor.orcidMarks, Florian [0000-0002-6043-7170]
dc.identifier.eissn1537-6591
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-05-09


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)