2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy.
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Authors
Li, Jingmei
Lindström, Linda S
Foo, Jia N
Rafiq, Sajjad
Schmidt, Marjanka K
Michailidou, Kyriaki
Bolla, Manjeet K
Van 't Veer, Laura J
Cornelissen, Sten
Rutgers, Emiel
Southey, Melissa C
Apicella, Carmel
Dite, Gillian S
Hopper, John L
Fasching, Peter A
Haeberle, Lothar
Ekici, Arif B
Beckmann, Matthias W
Blomqvist, Carl
Muranen, Taru A
Aittomäki, Kristiina
Lindblom, Annika
Margolin, Sara
Mannermaa, Arto
Kosma, Veli-Matti
Hartikainen, Jaana M
Kataja, Vesa
Chenevix-Trench, Georgia
kConFab Investigators
Phillips, Kelly-Anne
McLachlan, Sue-Anne
Lambrechts, Diether
Thienpont, Bernard
Smeets, Ann
Wildiers, Hans
Chang-Claude, Jenny
Flesch-Janys, Dieter
Seibold, Petra
Rudolph, Anja
Giles, Graham G
Baglietto, Laura
Severi, Gianluca
Haiman, Christopher A
Henderson, Brian E
Schumacher, Fredrick
Le Marchand, Loic
Kristensen, Vessela
Alnæs, Grethe I Grenaker
Borresen-Dale, Anne-Lise
Nord, Silje
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Andrulis, Irene L
Knight, Julia A
Glendon, Gord
Tchatchou, Sandrine
Devilee, Peter
Tollenaar, Robert
Seynaeve, Caroline
Hooning, Maartje
Kriege, Mieke
Hollestelle, Antoinette
van den Ouweland, Ans
Li, Yi
Hamann, Ute
Torres, Diana
Ulmer, Hans U
Rüdiger, Thomas
Shen, Chen-Yang
Hsiung, Chia-Ni
Wu, Pei-Ei
Chen, Shou-Tung
Teo, Soo Hwang
Taib, Nur Aishah Mohd
Har Yip, Cheng
Fuang Ho, Gwo
Matsuo, Keitaro
Ito, Hidemi
Iwata, Hiroji
Tajima, Kazuo
Kang, Daehee
Choi, Ji-Yeob
Park, Sue K
Yoo, Keun-Young
Maishman, Tom
Tapper, William J
Shah, Mitul
Brown, Judith
Khor, Chiea Chuen
Eccles, Diana M
Nevanlinna, Heli
Humphreys, Keith
Liu, Jianjun
Hall, Per
Czene, Kamila
Publication Date
2014-06-17Journal Title
Nat Commun
ISSN
2041-1723
Publisher
Springer Science and Business Media LLC
Volume
5
Pages
4051
Language
eng
Type
Article
Physical Medium
Electronic
Metadata
Show full item recordCitation
Li, J., Lindström, L. S., Foo, J. N., Rafiq, S., Schmidt, M. K., Pharoah, P., Michailidou, K., et al. (2014). 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy.. Nat Commun, 5 4051. https://doi.org/10.1038/ncomms5051
Abstract
Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.
Keywords
kConFab Investigators, Chromosomes, Human, Pair 2, Humans, Breast Neoplasms, Genetic Markers, Prognosis, Drug Therapy, Proportional Hazards Models, Linkage Disequilibrium, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Female, Kaplan-Meier Estimate
Sponsorship
National Cancer Institute (U19CA148537)
National Cancer Institute (R01CA128978)
National Cancer Institute (U19CA148065)
European Commission (223175)
Cancer Research UK (CRUK-A10710)
Cancer Research UK (CRUK-A12014)
Cancer Research UK (CRUK-A10118)
Breast Cancer Now (2010NovPR62)
Identifiers
External DOI: https://doi.org/10.1038/ncomms5051
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280096
Rights
Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
Licence URL: https://creativecommons.org/licenses/by-nc-sa/4.0/
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