Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma.

Caumanns, Joseph J; Berns, Katrien; Wisman, G Bea A; Fehrmann, Rudolf SN; Tomar, Tushar; Klip, Harry; Meersma, Gert J; Hijmans, E Marielle; Gennissen, Annemiek MC; Duiker, Evelien W; Weening, Desiree; Itamochi, Hiroaki; Kluin, Roelof JC; Reyners, Anna KL; Birrer, Michael J; Salvesen, Helga B; Vergote, Ignace; van Nieuwenhuysen, Els; Brenton, James; Braicu, E Ioana; Kupryjanczyk, Jolanta; Spiewankiewicz, Beata; Mittempergher, Lorenza; Bernards, René; van der Zee, Ate GJ; de Jong, Steven

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Authors

Caumanns, Joseph J

Berns, Katrien

Wisman, G Bea A

Fehrmann, Rudolf SN

Tomar, Tushar

Klip, Harry

Meersma, Gert J

Publication Date

2018-08

Journal Title

Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN

1078-0432

Volume

Issue

Pages

3928-3940

Language

eng

Type

Article

Physical Medium

Print-Electronic

Metadata

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Citation

Caumanns, J. J., Berns, K., Wisman, G. B. A., Fehrmann, R. S., Tomar, T., Klip, H., Meersma, G. J., et al. (2018). Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma.. Clinical cancer research : an official journal of the American Association for Cancer Research, 24 (16), 3928-3940. https://doi.org/10.1158/1078-0432.ccr-17-3060

Keywords

Cell Line, Tumor, Animals, Humans, Mice, Adenocarcinoma, Clear Cell, Ovarian Neoplasms, Morpholines, Nuclear Proteins, Transcription Factors, Signal Transduction, Cell Proliferation, Gene Expression Regulation, Neoplastic, Mutation, Female, Class I Phosphatidylinositol 3-Kinases, Heterografts, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2

Sponsorship

Cancer Research UK (CB4150)

Cancer Research UK (CRUK-A15601)

Identifiers

External DOI: https://doi.org/10.1158/1078-0432.ccr-17-3060

This record's URL: https://www.repository.cam.ac.uk/handle/1810/280097

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