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dc.contributor.authorLodge, Katharineen
dc.contributor.authorHoenderdos, Ken
dc.contributor.authorRobbins, AJen
dc.contributor.authorStoristeanu, DMen
dc.contributor.authorChilvers, Edwinen
dc.contributor.authorLi, Weien
dc.contributor.authorCondliffe, AMen
dc.date.accessioned2018-09-11T07:58:11Z
dc.date.available2018-09-11T07:58:11Z
dc.date.issued2016-11-15en
dc.identifier.issn0040-6376
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280112
dc.description.abstractIntroduction: COPD is a progressive inflammatory lung disease with multiple systemic complications, including pulmonary hypertension and cardiovascular disease (independent of smoking status). Airway neutrophilia correlates with disease severity and neutrophil elastase has been implicated in COPD pathogenesis, but precise mechanisms of tissue damage are unknown. Inflamed COPD airways are profoundly hypoxic, and this tissue hypoxia may synergise with inflammatory cytokines to promote a destructive neutrophil phenotype with enhanced potential for tissue damage.
dc.language.isoenen
dc.titleHYPOXIA UPREGULATES PI3KINASE-DEPENDENT NEUTROPHIL DEGRANULATION AND NEUTROPHIL-MEDIATED TISSUE INJURYen
dc.typeConference Object
prism.endingPageA27
prism.publicationDate2016en
prism.publicationNameTHORAXen
prism.startingPageA27
prism.volume71en
dc.identifier.doi10.17863/CAM.21669
rioxxterms.versionofrecord10.1136/thoraxjnl-2016-209333.49en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-11-15en
dc.contributor.orcidChilvers, Edwin [0000-0002-4230-9677]
dc.contributor.orcidLi, Wei [0000-0002-1924-3120]
dc.identifier.eissn1468-3296
rioxxterms.typeConference Paper/Proceeding/Abstracten
pubs.funder-project-idWellcome Trust (102706/Z/13/Z)
pubs.funder-project-idBritish Heart Foundation (PG/12/54/29734)
pubs.funder-project-idBritish Heart Foundation (PG/17/1/32532)
pubs.funder-project-idBritish Heart Foundation (PG/15/39/31519)
pubs.conference-nameBritish Thoracic Society Annual meetingen
rioxxterms.freetoread.startdate2017-12-31


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