Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.
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Authors
Mohan, Divya
Forman, Julia R
Allinder, Matthew
McEniery, Carmel M
Bolton, Charlotte Emma
Cockcroft, John R
MacNee, William
Marchong, Mellone
Gale, Nichola Sian
Nagarajan, Sridevi
Lomas, David A
Calverley, Peter MA
Miller, Bruce E
Tal-Singer, Ruth
Wilkinson, Ian B
Polkey, Michael I
ERICA Consortium
Publication Date
2018-12Journal Title
Thorax
ISSN
0040-6376
Publisher
BMJ
Volume
73
Issue
12
Pages
1182-1185
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Mohan, D., Forman, J. R., Allinder, M., McEniery, C. M., Bolton, C. E., Cockcroft, J. R., MacNee, W., et al. (2018). Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.. Thorax, 73 (12), 1182-1185. https://doi.org/10.1136/thoraxjnl-2018-211556
Abstract
Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and quadriceps weakness are linked in COPD, and whether they are associated with the systemic inflammatory mediator-fibrinogen. Aortic pulse wave velocity (aPWV), quadriceps maximal volitional contraction (QMVC) force and fibrinogen were measured in 729 patients with stable, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages II-IV COPD. The cardiovascular and muscular manifestations exist independently (P=0.22, χ2). Fibrinogen was not associated with aPWV or QMVC (P=0.628 and P=0.621, respectively), making inflammation, as measured by plasma fibrinogen, an unlikely common aetiological factor.
Keywords
copd pathology, Aged, Aorta, Cross-Sectional Studies, Female, Fibrinogen, Humans, Male, Middle Aged, Muscle Contraction, Muscle Weakness, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Pulse Wave Analysis, Quadriceps Muscle, Vascular Stiffness
Sponsorship
NIHR West Anglia Comprehensive Local Research Network (CLRN) (via Cambridge University Hospitals NHS Foundation Trust (CUH)) (RCF FUNDING 2013/14)
Technology Strategy Board (101024 TP 9157-61188)
British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation (None)
Identifiers
External DOI: https://doi.org/10.1136/thoraxjnl-2018-211556
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280176
Rights
Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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