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dc.contributor.authorMarti Ruiz, Maria Carmen
dc.contributor.authorHubbard, Katharine
dc.contributor.authorGardner, Michael
dc.contributor.authorJung, Hyun Ju
dc.contributor.authorAubry, Sylain
dc.contributor.authorHotta, Carlos
dc.contributor.authorMohd-Noh, Nur Izzati
dc.contributor.authorRobertson, Fiona
dc.contributor.authorHearn, Timothy
dc.contributor.authorTsai, Yu-Chang
dc.contributor.authorHannah, Matthew
dc.contributor.authorCarre, Isabelle
dc.contributor.authorDavies, Julia
dc.contributor.authorBraam, Janet
dc.contributor.authorWebb, AAR
dc.date.accessioned2018-09-11T17:32:37Z
dc.date.available2018-09-11T17:32:37Z
dc.date.issued2018-09
dc.identifier.issn2055-026X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280204
dc.description.abstractIn the last decade, the view of circadian oscillators has expanded from transcriptional feedback to incorporate post-transcriptional, post-translational, metabolic processes and ionic signalling. In plants and animals, there are circadian oscillations in the concentration of cytosolic-free Ca2+ ([Ca2+]cyt), though their purpose has not been fully characterised. We investigated whether circadian oscillations of [Ca2+] cyt regulate the circadian oscillator of Arabidopsis thaliana. We report that in Arabidopsis, [Ca2+]cyt circadian oscillations can regulate circadian clock function through the Ca2+-dependent action of CALMODULIN-LIKE24 (CML24). Genetic analyses demonstrate a linkage between CML24 and the circadian oscillator, through pathways involving the circadian oscillator gene TIMING OF CAB2 EXPRESSION1 (TOC1).
dc.description.sponsorshipSupported by BBSRC UK research grants BBSRC BB/D010381/1 (A.N.D.), BB/D017904/1 (F.R.) BB/M00113X/1 (H.J.H.) awarded to (A.A.R.W.), Research Studentship (K.H.) and BBSRC Industrial Case (T.H.). A Swiss Science Foundation Award (PBZHP3-123289) and the Isaac Newton Trust Cambridge (M.C.M.R. and S.A.), 678 the National Science Foundation under Grant No. MCB 0817976 (Y-C.T. and J.B.), a Royal Society Grant RG081257 and Corpus Christi College, Cambridge Junior Research Fellowship (M.J.G.), a Cordenadoria de Apoio ao Ensino Superior Brazil 25681 studentship (C.T.H.), IEF Marrie Curie (Project No. 272186) (M.C.M.R.), a Broodbank Fellowship (M.C.M.R.), a Malaysian Government Studentship (N.I.M-H.).
dc.publisherSpringer Nature
dc.titleCircadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock
dc.typeArticle
prism.endingPage698
prism.publicationNameNature Plants
prism.startingPage690
prism.volume4
dc.identifier.doi10.17863/CAM.27571
dcterms.dateAccepted2018-07-17
rioxxterms.versionofrecord10.1038/s41477-018-0224-8
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07-17
dc.contributor.orcidHearn, Timothy [0000-0001-6827-4196]
dc.contributor.orcidWebb, Alex [0000-0003-0261-4375]
dc.identifier.eissn2055-0278
rioxxterms.typeJournal Article/Review
pubs.funder-project-idIsaac Newton Trust (MINUTE 707 (n))
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/D017904/1)
pubs.funder-project-idEuropean Commission (272186)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M00113X/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M006212/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/L02182X/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/D010381/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/H006826/1)
cam.issuedOnline2018-08-20
rioxxterms.freetoread.startdate2019-02-20


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