Skin Sodium and Hypertension: a Paradigm Shift?

Authors
Selvarajah, Viknesh 

Change log
Abstract

PURPOSE OF REVIEW: Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure response to salt intake. The precise mechanisms for this have not been fully explained although renal sodium handling has traditionally been considered to play a central role. RECENT FINDINGS: Animal studies have shown that dietary salt loading results in non-osmotic sodium accumulation via glycosaminoglycans and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C, both processes attenuating the rise in BP. Studies in humans have shown that skin could be a buffer for sodium and that skin sodium could be a marker of hypertension and salt sensitivity. Skin sodium storage could represent an additional system influencing the response to salt load and blood pressure in humans.

Publication Date
2018-09-13
Online Publication Date
2018-09-13
Acceptance Date
2018-08-14
Keywords
Blood pressure, Salt, Skin, Sodium, VEGF-C, Animals, Hemodynamics, Humans, Hypertension, Lymphoid Tissue, Macrophages, Magnetic Resonance Spectroscopy, Skin, Sodium, Sodium, Dietary, Vascular Endothelial Growth Factor C
Journal Title
Curr Hypertens Rep
Journal ISSN
1522-6417
1534-3111
Volume Title
20
Publisher
Springer Science and Business Media LLC
Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Wellcome Trust (207166/Z/17/Z)
British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation NIHR Addenbrookes Charitable Trust