Skin Sodium and Hypertension: a Paradigm Shift?
Publication Date
2018-09-13Journal Title
Curr Hypertens Rep
ISSN
1522-6417
Publisher
Springer Science and Business Media LLC
Volume
20
Issue
11
Pages
94
Language
eng
Type
Article
Physical Medium
Electronic
Metadata
Show full item recordCitation
Selvarajah, V., Connolly, K., McEniery, C., & Wilkinson, I. (2018). Skin Sodium and Hypertension: a Paradigm Shift?. Curr Hypertens Rep, 20 (11), 94. https://doi.org/10.1007/s11906-018-0892-9
Abstract
PURPOSE OF REVIEW: Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure response to salt intake. The precise mechanisms for this have not been fully explained although renal sodium handling has traditionally been considered to play a central role. RECENT FINDINGS: Animal studies have shown that dietary salt loading results in non-osmotic sodium accumulation via glycosaminoglycans and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C, both processes attenuating the rise in BP. Studies in humans have shown that skin could be a buffer for sodium and that skin sodium could be a marker of hypertension and salt sensitivity. Skin sodium storage could represent an additional system influencing the response to salt load and blood pressure in humans.
Keywords
Lymphoid Tissue, Macrophages, Skin, Animals, Humans, Hypertension, Sodium, Sodium, Dietary, Vascular Endothelial Growth Factor C, Magnetic Resonance Spectroscopy, Hemodynamics
Sponsorship
British Heart Foundation
NIHR
Addenbrookes Charitable Trust
Funder references
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Wellcome Trust (207166/Z/17/Z)
British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation (None)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1007/s11906-018-0892-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280222
Rights
Licence:
http://www.rioxx.net/licenses/all-rights-reserved
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.