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dc.contributor.authorInshaw, JRJ
dc.contributor.authorCutler, AJ
dc.contributor.authorBurren, OS
dc.contributor.authorStefana, MI
dc.contributor.authorTodd, JA
dc.date.accessioned2018-09-13T13:24:44Z
dc.date.available2018-09-13T13:24:44Z
dc.date.issued2018-06-20
dc.identifier.issn1529-2908
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280256
dc.description.abstractGenome-wide association studies are transformative in revealing the polygenetic basis of common diseases, with autoimmune diseases leading the charge. Although the field is just over 10 years old, advances in understanding the underlying mechanistic pathways of these conditions, which result from a dense multifactorial blend of genetic, developmental and environmental factors, have already been informative, including insights into therapeutic possibilities. Nevertheless, the challenge of identifying the actual causal genes and pathways and their biological effects on altering disease risk remains for many identified susceptibility regions. It is this fundamental knowledge that will underpin the revolution in patient stratification, the discovery of therapeutic targets and clinical trial design in the next 20 years. Here we outline recent advances in analytical and phenotyping approaches and the emergence of large cohorts with standardized gene-expression data and other phenotypic data that are fueling a bounty of discovery and improved understanding of human physiology.
dc.languageeng
dc.publisherSpringer Nature
dc.titleApproaches and advances in the genetic causes of autoimmune disease and their implications
dc.typeArticle
prism.endingPage684
prism.publicationDate2018
prism.publicationNameNature Immunology
prism.startingPage674
prism.volume19
dc.identifier.doi10.17863/CAM.27625
dcterms.dateAccepted2018-04-04
rioxxterms.versionofrecord10.1038/s41590-018-0129-8
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-06-20
dc.contributor.orcidBurren, Oliver [0000-0002-3388-5760]
dc.identifier.eissn1529-2916
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (107881/Z/15/Z)
cam.issuedOnline2018-06-20
rioxxterms.freetoread.startdate2018-12-20


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