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dc.contributor.authorMerino, Jordi
dc.contributor.authorDashti, Hassan S
dc.contributor.authorLi, Sherly X
dc.contributor.authorSarnowski, Chloé
dc.contributor.authorJustice, Anne E
dc.contributor.authorGraff, Misa
dc.contributor.authorPapoutsakis, Constantina
dc.contributor.authorSmith, Caren E
dc.contributor.authorDedoussis, George V
dc.contributor.authorLemaitre, Rozenn N
dc.contributor.authorWojczynski, Mary K
dc.contributor.authorMännistö, Satu
dc.contributor.authorNgwa, Julius S
dc.contributor.authorKho, Minjung
dc.contributor.authorAhluwalia, Tarunveer S
dc.contributor.authorPervjakova, Natalia
dc.contributor.authorHouston, Denise K
dc.contributor.authorBouchard, Claude
dc.contributor.authorHuang, Tao
dc.contributor.authorOrho-Melander, Marju
dc.contributor.authorFrazier-Wood, Alexis C
dc.contributor.authorMook-Kanamori, Dennis O
dc.contributor.authorPérusse, Louis
dc.contributor.authorPennell, Craig E
dc.contributor.authorde Vries, Paul S
dc.contributor.authorVoortman, Trudy
dc.contributor.authorLi, Olivia
dc.contributor.authorKanoni, Stavroula
dc.contributor.authorRose, Lynda M
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorFeitosa, Mary F
dc.contributor.authorLuan, Jian'an
dc.contributor.authorMcKeown, Nicola M
dc.contributor.authorSmith, Jennifer A
dc.contributor.authorHansen, Torben
dc.contributor.authorEklund, Niina
dc.contributor.authorNalls, Mike A
dc.contributor.authorRankinen, Tuomo
dc.contributor.authorHuang, Jinyan
dc.contributor.authorHernandez, Dena G
dc.contributor.authorSchulz, Christina-Alexandra
dc.contributor.authorManichaikul, Ani
dc.contributor.authorLi-Gao, Ruifang
dc.contributor.authorVohl, Marie-Claude
dc.contributor.authorWang, Carol A
dc.contributor.authorvan Rooij, Frank JA
dc.contributor.authorShin, Jean
dc.contributor.authorKalafati, Ioanna P
dc.contributor.authorDay, Felix
dc.contributor.authorRidker, Paul M
dc.contributor.authorKähönen, Mika
dc.contributor.authorSiscovick, David S
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorZhao, Wei
dc.contributor.authorAstrup, Arne
dc.contributor.authorKnekt, Paul
dc.contributor.authorGarcia, Melissa
dc.contributor.authorRao, DC
dc.contributor.authorQi, Qibin
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorEricson, Ulrika
dc.contributor.authorBlangero, John
dc.contributor.authorHofman, Albert
dc.contributor.authorPausova, Zdenka
dc.contributor.authorMikkilä, Vera
dc.contributor.authorWareham, Nicholas
dc.contributor.authorKardia, Sharon LR
dc.contributor.authorPedersen, Oluf
dc.contributor.authorJula, Antti
dc.contributor.authorCurran, Joanne E
dc.contributor.authorZillikens, M Carola
dc.contributor.authorViikari, Jorma S
dc.contributor.authorForouhi, Nita
dc.contributor.authorOrdovás, José M
dc.contributor.authorLieske, John C
dc.contributor.authorRissanen, Harri
dc.contributor.authorUitterlinden, André G
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorKiefte-de Jong, Jessica C
dc.contributor.authorDupuis, Josée
dc.contributor.authorRotter, Jerome I
dc.contributor.authorNorth, Kari E
dc.contributor.authorScott, Robert A
dc.contributor.authorProvince, Michael A
dc.contributor.authorPerola, Markus
dc.contributor.authorCupples, L Adrienne
dc.contributor.authorTurner, Stephen T
dc.contributor.authorSørensen, Thorkild IA
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorLiu, Yongmei
dc.contributor.authorSung, Yun J
dc.contributor.authorQi, Lu
dc.contributor.authorBandinelli, Stefania
dc.contributor.authorRich, Stephen S
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorTremblay, Angelo
dc.contributor.authorOddy, Wendy H
dc.contributor.authorFranco, Oscar H
dc.contributor.authorPaus, Tomas
dc.contributor.authorFlorez, Jose C
dc.contributor.authorDeloukas, Panos
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorChasman, Daniel I
dc.contributor.authorChu, Audrey Y
dc.contributor.authorTanaka, Toshiko
dc.date.accessioned2018-09-19T13:30:39Z
dc.date.available2018-09-19T13:30:39Z
dc.date.issued2018-07-09
dc.identifier.issn1476-5578
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280348
dc.description.abstractMacronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P < 1 × 10-6) associated with intake of any macronutrient in 91,114 European ancestry participants. Four loci replicated and reached genome-wide significance in a combined meta-analysis including 123,659 European descent participants, unraveling two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings. In additional analysis of 144,770 participants from the UK Biobank, all identified associations from the two-stage analysis were confirmed except for DRAM1. Identified loci might have implications in brain and adipose tissue biology and have clinical impact in obesity-related phenotypes. Our findings provide new insight into biological functions related to macronutrient intake.
dc.languageeng
dc.publisherSpringer Nature
dc.titleGenome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.
dc.typeArticle
prism.publicationDate2018
prism.publicationNameMolecular Psychiatry
dc.identifier.doi10.17863/CAM.27719
dcterms.dateAccepted2018-04-10
rioxxterms.versionofrecord10.1038/s41380-018-0079-4
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07-09
dc.contributor.orcidZhao, Jing Hua [0000-0003-4930-3582]
dc.contributor.orcidLuan, Jian'an [0000-0003-3137-6337]
dc.contributor.orcidDay, Felix [0000-0003-3789-7651]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.identifier.eissn1476-5578
dc.publisher.urlhttps://www.nature.com/articles/s41380-018-0079-4
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMRC (MC_PC_13048)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idMedical Research Council (MC_UU_12015/5)
pubs.funder-project-idMedical Research Council (MC_UU_12015/2)
cam.issuedOnline2018-07-09
dc.identifier.urlhttps://www.nature.com/articles/s41380-018-0079-4
rioxxterms.freetoread.startdate2019-07-09


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