Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Authors
Cayssials, Valerie
Jenab, Mazda
Rothwell, Joseph A
Fedirko, Veronika
Aleksandrova, Krasimira
Tjønneland, Anne
Kyrø, Cecilie
Overvad, Kim
Boutron-Ruault, Marie-Christine
Carbonnel, Franck
Mahamat-Saleh, Yahya
Kaaks, Rudolf
Kühn, Tilman
Boeing, Heiner
Trichopoulou, Antonia
Valanou, Elissavet
Vasilopoulou, Effie
Masala, Giovanna
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Ricceri, Fulvio
Weiderpass, Elisabete
Lukic, Marko
Sandanger, Torkjel M
Lasheras, Cristina
Agudo, Antonio
Sánchez, Maria-Jose
Amiano, Pilar
Navarro, Carmen
Ardanaz, Eva
Sonestedt, Emily
Ohlsson, Bodil
Nilsson, Lena Maria
Rutegård, Martin
Bueno-de-Mesquita, Bas
Peeters, Petra H
Bradbury, Kathryn
Freisling, Heinz
Romieu, Isabelle
Cross, Amanda J
Vineis, Paolo
Scalbert, Augustin
Publication Date
2018-11Journal Title
Eur J Epidemiol
ISSN
0393-2990
Publisher
Springer Science and Business Media LLC
Volume
33
Issue
11
Pages
1063-1075
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Zamora-Ros, R., Cayssials, V., Jenab, M., Rothwell, J. A., Fedirko, V., Aleksandrova, K., Tjønneland, A., et al. (2018). Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.. Eur J Epidemiol, 33 (11), 1063-1075. https://doi.org/10.1007/s10654-018-0408-6
Abstract
Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.
Keywords
Humans, Colorectal Neoplasms, Nutrition Assessment, Cohort Studies, Follow-Up Studies, Prospective Studies, Coffee, Tea, Adult, Aged, Middle Aged, Europe, Female, Male, Polyphenols, Surveys and Questionnaires
Sponsorship
Medical Research Council (MR/N003284/1)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
Medical Research Council (MC_UU_12015/1)
Identifiers
External DOI: https://doi.org/10.1007/s10654-018-0408-6
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280429
Rights
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