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dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorCayssials, Valerie
dc.contributor.authorJenab, Mazda
dc.contributor.authorRothwell, Joseph A
dc.contributor.authorFedirko, Veronika
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKyrø, Cecilie
dc.contributor.authorOvervad, Kim
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorCarbonnel, Franck
dc.contributor.authorMahamat-Saleh, Yahya
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorValanou, Elissavet
dc.contributor.authorVasilopoulou, Effie
dc.contributor.authorMasala, Giovanna
dc.contributor.authorPala, Valeria
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorLukic, Marko
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorLasheras, Cristina
dc.contributor.authorAgudo, Antonio
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorAmiano, Pilar
dc.contributor.authorNavarro, Carmen
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSonestedt, Emily
dc.contributor.authorOhlsson, Bodil
dc.contributor.authorNilsson, Lena Maria
dc.contributor.authorRutegård, Martin
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorPeeters, Petra H
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nicholas
dc.contributor.authorBradbury, Kathryn
dc.contributor.authorFreisling, Heinz
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorCross, Amanda J
dc.contributor.authorVineis, Paolo
dc.contributor.authorScalbert, Augustin
dc.date.accessioned2018-09-20T12:02:58Z
dc.date.available2018-09-20T12:02:58Z
dc.date.issued2018-11
dc.identifier.issn0393-2990
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280429
dc.description.abstractPolyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectHumans
dc.subjectColorectal Neoplasms
dc.subjectNutrition Assessment
dc.subjectCohort Studies
dc.subjectFollow-Up Studies
dc.subjectProspective Studies
dc.subjectCoffee
dc.subjectTea
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectEurope
dc.subjectFemale
dc.subjectMale
dc.subjectPolyphenols
dc.subjectSurveys and Questionnaires
dc.titleDietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
dc.typeArticle
prism.endingPage1075
prism.issueIdentifier11
prism.publicationDate2018
prism.publicationNameEur J Epidemiol
prism.startingPage1063
prism.volume33
dc.identifier.doi10.17863/CAM.27800
dcterms.dateAccepted2018-05-04
rioxxterms.versionofrecord10.1007/s10654-018-0408-6
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11
dc.contributor.orcidZamora-Ros, Raul [0000-0002-6236-6804]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1573-7284
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/N003284/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
cam.issuedOnline2018-05-15
rioxxterms.freetoread.startdate2019-05-15


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