Structure and mechanism of bacterial tripartite efflux pumps.
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Publication Date
2018-09Journal Title
Research in microbiology
ISSN
0923-2508
Publisher
Elsevier
Volume
169
Issue
7-8
Pages
401-413
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Neuberger, A., Du, D., & Luisi, B. (2018). Structure and mechanism of bacterial tripartite efflux pumps.. Research in microbiology, 169 (7-8), 401-413. https://doi.org/10.1016/j.resmic.2018.05.003
Abstract
Efflux pumps are membrane proteins which contribute to multi-drug resistance. In Gram-negative bacteria, some of these pumps form complex tripartite assemblies in association with an outer membrane channel and a periplasmic fusion protein. These tripartite machineries span both membranes and the periplasmic space, and they extrude from the bacterium chemically diverse toxic substrates. In this chapter, we summarise current understanding of the structural architecture, functionality, and regulation of tripartite multi-drug efflux assemblies.
Keywords
Gram-Negative Bacteria, Bacterial Proteins, Membrane Transport Proteins, Protein Conformation, Models, Molecular
Sponsorship
ERC
Funder references
Human Frontier Science Program (HFSP) (RPG0034/2013)
European Commission Horizon 2020 (H2020) ERC (742210)
Identifiers
External DOI: https://doi.org/10.1016/j.resmic.2018.05.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280434
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