The devil is in the mesoscale: Mechanical and behavioural heterogeneity in collective cell movement.
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Authors
Blanchard, Guy B
Fletcher, Alexander G
Schumacher, Linus J
Publication Date
2019-09Journal Title
Semin Cell Dev Biol
ISSN
1084-9521
Publisher
Elsevier BV
Volume
93
Pages
46-54
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Blanchard, G. B., Fletcher, A. G., & Schumacher, L. J. (2019). The devil is in the mesoscale: Mechanical and behavioural heterogeneity in collective cell movement.. Semin Cell Dev Biol, 93 46-54. https://doi.org/10.1016/j.semcdb.2018.06.003
Abstract
Heterogeneity within cell populations can be an important aspect affecting their collective movement and tissue-mechanical properties, determining for example their effective viscoelasticity. Differences in cell-level properties and behaviour within a group of moving cells can give rise to unexpected and non-intuitive behaviours at the tissue level. Such emergent phenomena often manifest themselves through spatiotemporal patterns at an intermediate 'mesoscale' between cell and tissue scales, typically involving tens of cells. Focussing on the development of embryonic animal tissues, we review recent evidence for the importance of heterogeneity at the mesoscale for collective cell migration and convergence and extension movements. We further discuss approaches to incorporate heterogeneity into computational models to complement experimental investigations.
Keywords
Collective cell migration, Convergence and extension, Heterogeneity, Mesoscale, Tissue mechanics, Cell Movement, Humans
Sponsorship
GBB acknowledges the Wellcome Trust Investigator Award 099234/Z/12/Z to Bénédicte Sanson. AGF is supported by a Vice-Chancellor’s Fellowship from the University of Sheffield. LJS is supported by a Chancellor’s Fellowship from the University of Edinburgh.
Funder references
Wellcome Trust (099234/Z/12/Z)
Biotechnology and Biological Sciences Research Council (BB/J010278/1)
Identifiers
External DOI: https://doi.org/10.1016/j.semcdb.2018.06.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280507
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