The Role of DNA Repair in Maintaining Mitochondrial DNA Stability.
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Authors
Zhang, Linlin
Reyes, Aurelio
Wang, Xiangdong
Publication Date
2017Journal Title
Adv Exp Med Biol
ISSN
0065-2598
Publisher
Springer Singapore
Volume
1038
Pages
85-105
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Zhang, L., Reyes, A., & Wang, X. (2017). The Role of DNA Repair in Maintaining Mitochondrial DNA Stability.. Adv Exp Med Biol, 1038 85-105. https://doi.org/10.1007/978-981-10-6674-0_7
Abstract
Mitochondria are vital double-membrane organelles that act as a "powerhouse" inside the cell and have essential roles to maintain cellular functions, e.g., ATP production, iron-sulfur synthesis metabolism, and steroid synthesis. An important difference with other organelles is that they contain their own mitochondrial DNA (mtDNA). Such powerful organelles are also sensitive to both endogenous and exogenous factors that can cause lesions to their structural components and their mtDNA, resulting in gene mutations and eventually leading to diseases. In this review, we will mainly focus on mammalian mitochondrial DNA repair pathways that safeguard mitochondrial DNA integrity and several important factors involved in the repair process, especially on an essential pathway, base excision repair. We eagerly anticipate to explore more methods to treat related diseases by constantly groping for these complexes and precise repair mechanisms.
Keywords
BER, DNA repair, Lesions, Major pathway, Mitochondrial DNA, Animals, DNA Repair, DNA, Mitochondrial, Genomic Instability, Humans, Mitochondria
Identifiers
External DOI: https://doi.org/10.1007/978-981-10-6674-0_7
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280516
Rights
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http://www.rioxx.net/licenses/all-rights-reserved
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