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dc.contributor.authorGrant, Jon E
dc.contributor.authorDaws, Richard
dc.contributor.authorHampshire, Adam
dc.contributor.authorChamberlain, Samuel R
dc.date.accessioned2018-09-20T12:38:57Z
dc.date.available2018-09-20T12:38:57Z
dc.date.issued2018
dc.identifier.issn0895-0172
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280589
dc.description.abstractTrichotillomania is a relatively common psychiatric condition, although its neurobiological basis is unknown. Abnormalities of flexible responding have been implicated in the pathophysiology of obsessive-compulsive disorder and thus may be relevant in trichotillomania. The purpose of this study was to probe reversal learning and attentional set-shifting in trichotillomania. Twelve adults with trichotillomania and 13 matched healthy control subjects undertook a functional MRI task of cognitive flexibility. Group-level activation maps for extradimensional and reversal switches were independently parcellated into discrete regions of interest using a custom watershed algorithm. Activation magnitudes were extracted from each region of interest and study subject and compared at the group level. Reversal events evoked the expected patterns of insula and parietal regions and activity in the frontal dorsal cortex extending anterior to the frontal poles, whereas extradimensional shifts evoked the expected frontal dorsolateral and parietal pattern of activity. Trichotillomania was associated with significantly increased right middle frontal and reduced right occipital cortex activation during reversal and set-shifting. Elevated frontal activation coupled with reduced activation in more posterior brain regions was identified. These pilot data suggest potentially important neural dysfunction associated with trichotillomania.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherAmerican Psychiatric Association Publishing
dc.subjectBrain
dc.subjectHumans
dc.subjectCognition
dc.subjectPsychomotor Performance
dc.subjectReaction Time
dc.subjectTrichotillomania
dc.subjectBrief Psychiatric Rating Scale
dc.subjectNeuropsychological Tests
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.subjectFunctional Neuroimaging
dc.titleAn fMRI Pilot Study of Cognitive Flexibility in Trichotillomania.
dc.typeArticle
prism.endingPage324
prism.issueIdentifier4
prism.publicationDate2018
prism.publicationNameJ Neuropsychiatry Clin Neurosci
prism.startingPage318
prism.volume30
dc.identifier.doi10.17863/CAM.27956
dcterms.dateAccepted2018-08-28
rioxxterms.versionofrecord10.1176/appi.neuropsych.18030038
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidChamberlain, Samuel [0000-0001-7014-8121]
dc.identifier.eissn1545-7222
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (110049/Z/15/Z)
cam.issuedOnline2018-08-24
rioxxterms.freetoread.startdate2019-08-24


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