Evolutionary dynamics in pre-invasive neoplasia.
Janes, Samuel M
Fitzgerald, Rebecca C
Curr Opin Syst Biol
MetadataShow full item record
Abbosh, C., Venkatesan, S., Janes, S. M., Fitzgerald, R. C., & Swanton, C. (2017). Evolutionary dynamics in pre-invasive neoplasia.. Curr Opin Syst Biol, 2 1-8. https://doi.org/10.1016/j.coisb.2017.02.009
Mutational processes occur in normal tissues from conception throughout life. Field cancerization describes the preconditioning of an area of epithelium to tumor growth. Pre-invasive lesions may arise in these fields, however only a minority of pre-invasive neoplasia progresses to overt malignancy. Within this review we discuss recent advances in our understanding of genomic instability processes in normal tissue, describe evolutionary dynamics in pre-invasive disease and highlight current evidence describing how increasing genomic instability may drive the transition from pre-invasive to invasive disease. Appreciation of the evolutionary rulebooks that operate in pre-invasive neoplasia may facilitate screening strategies, risk-stratification of pre-invasive lesions and precipitate novel preventative treatments in at-risk patient populations.
Intratumor heterogeneity, cancer evolution, field cancerization, genomic instability, pre-invasive neoplasia
External DOI: https://doi.org/10.1016/j.coisb.2017.02.009
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280655
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