Show simple item record

dc.contributor.authorKwon, Joanne
dc.contributor.authorJuhasz, JA
dc.contributor.authorBrooks, Roger
dc.contributor.authorBest, Serena
dc.date.accessioned2018-09-24T10:32:22Z
dc.date.available2018-09-24T10:32:22Z
dc.date.issued2020-10-14
dc.identifier.issn1066-7857
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280678
dc.description.abstractA series of nanocomposite coatings was produced, comprising a hydrogel polymer, poly(2-hydroxyethyl methacrylate)/poly(ε-caprolactone) (PHEMA/PCL) matrix with nanoscale carbonated hydroxyapatite (nCHA) filler particles. The weight fraction of the filler was varied from 0 to 20% and the composites were applied as coatings onto Ti-6Al-4V substrates. The filler distribution and surface morphology were investigated by AFM, and the mechanical stability of the coatings was characterised using nanoindentation in both dry and wet conditions. The cellular response to the coatings was also examined in vitro using human osteoblast (HOB) cells. It was found that interfacial cracking occurred for composites containing greater than 10 wt.% nCHA and that 10 wt.% nCHA composite coatings appear to offer the greatest coating stability and bioactivity compared with the other composite coatings. It was concluded that the nCHA-containing PHEMA/PCL composite coatings had the potential to provide a soft, low modulus interface between metal implants and bone.
dc.languageeng
dc.publisherTaylor & Francis
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjecthydrogel
dc.subjectcarbonated hydroxyapatite
dc.subjectnanocomposite
dc.subjectcoating
dc.subjectTi-6Al-4V
dc.titleBioactive conformable hydrogel-carbonated hydroxyapatite nanocomposite coatings on Ti-6Al-4V substrates
dc.typeArticle
prism.publicationNameMaterials Technology: Advanced Performance Materials
dc.identifier.doi10.17863/CAM.28043
dcterms.dateAccepted2018-05-04
rioxxterms.versionofrecord10.1080/10667857.2018.1475143
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2018-05-04
dc.contributor.orcidBest, Serena [0000-0001-7866-8607]
dc.identifier.eissn1753-5557
dc.publisher.urlhttps://www.tandfonline.com/doi/full/10.1080/10667857.2018.1475143?scroll=top&needAccess=true
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-06-14
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/10667857.2018.1475143?scroll=top&needAccess=true
datacite.issupplementedby.doi10.17863/CAM.22807
cam.orpheus.successThu Jan 30 10:54:21 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International